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| ID | Type | Description | Link |
|---|---|---|---|
| 801968 | Other Identifier | UC San Diego | |
| Pro00115158 | Other Identifier | Duke University Health System |
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This study will investigate disparities in neurocognitive impairment (NCI) among Hispanics/Latinos/as/x (henceforth Hispanics) living in the US-Mexico borderland of California or in North Carolina with Parkinson's Disease (PD) and determine mechanisms underlying these disparities. NCI is an important aspect of the clinical course of PD, particularly among Hispanics, who have increased prevalence of dementia. Among the many potential factors driving this disparity, the investigators chose to focus on a modifiable risk factor to which Hispanics are particularly vulnerable, and that has been linked to increased NCI, namely cardiovascular (CVD) risk (e.g., diabetes, hypertension, obesity).
The proposed study will use a cross-sectional design to determine the presence of NCI in 120 persons with PD (age 40+), living in the US-Mexico borderland of California or in North Carolina, including 60 Hispanics and 60 non-Hispanic Whites. All participants will complete comprehensive neuromedical and neuropsychological evaluations, a blood draw and assessments of socio-cultural factors (e.g., health literacy, access to care, acculturation, bilingualism, discrimination, socioeconomic status). Using these data we will examine the extent to which CVD risk (e.g., diabetes, hypertension, obesity), PD severity and social determinants of health drive NCI among Hispanics with PD. The present proposal will capitalize on the infrastructure and expertise available at Duke University and will follow a community-based participatory research approach to complete the proposed study aims.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hispanics with Parkinson's Disease | All Hispanics with PD will complete comprehensive neuromedical and neuropsychological evaluations, a blood draw and assessments of socio-cultural factors (e.g., health literacy, access to care, acculturation, bilingualism, discrimination, socioeconomic status). |
| |
| non-Hispanic Whites with Parkinson's Disease | All non-Hispanic Whites with PD will complete comprehensive neuromedical and neuropsychological evaluations, a blood draw and assessments of socio-cultural factors (e.g., health literacy, access to care, acculturation, bilingualism, discrimination, socioeconomic status). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Will examine how Cardiovascular Disease risk, PD severity and social determinants impact neurocognitive impairment in Hispanics vs non-Hispanics Whites | Other | All participants will complete comprehensive neuromedical and neuropsychological evaluations, a blood draw and assessments of socio-cultural factors (e.g., health literacy, access to care, acculturation, bilingualism, discrimination, socioeconomic status). |
| Measure | Description | Time Frame |
|---|---|---|
| Language (Letter Fluency) | Day 1 (day of enrollment) | |
| Language (Animal Fluency) | Day 1 (day of enrollment) | |
| Language (Vegetable Fluency) | Day 1 (day of enrollment) | |
| Language (Multilingual Naming Test) | Day 1 (day of enrollment) | |
| Speed of Information Processing | Trail Making Test A | Day 1 (day of enrollment) |
| Speed of Information Processing | WAIS-III Digit Symbol | Day 1 (day of enrollment) |
| Speed of Information Processing | WAIS-III Symbol Search (Wechsler Adult Intelligence Scale) | Day 1 (day of enrollment) |
| Attention/Working Memory | PASAT-50 (Paced Auditory Serial Addition Test) | Day 1 (day of enrollment) |
| Attention/Working Memory | Number Span | Day 1 (day of enrollment) |
| Executive Function |
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Inclusion Criteria:
Exclusion Criteria:
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The proposed study will use a cross-sectional design to determine the presence of NCI in 120 persons with PD (age 40+), including 60 Hispanics and 60 non-Hispanic Whites living in the US/Mexico borderland of California or in North Carolina.
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| Name | Affiliation | Role |
|---|---|---|
| Maria J Marquine, PhD | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UC San Diego | La Jolla | California | 92037 | United States | ||
| Duke University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22275317 | Background | Litvan I, Goldman JG, Troster AI, Schmand BA, Weintraub D, Petersen RC, Mollenhauer B, Adler CH, Marder K, Williams-Gray CH, Aarsland D, Kulisevsky J, Rodriguez-Oroz MC, Burn DJ, Barker RA, Emre M. Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines. Mov Disord. 2012 Mar;27(3):349-56. doi: 10.1002/mds.24893. Epub 2012 Jan 24. | |
| 32431209 |
| Label | URL |
|---|---|
| recruitment flyer - Spanish | View source |
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Study is conducted only at these sites, hence there is no need to share information with other investigators.
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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|
Trail Making Test B |
| Day 1 (day of enrollment) |
| Executive Function | WCST-64 (Wisconsin Card Sorting Test) | Day 1 (day of enrollment) |
| Verbal Learning and Memory | Hopkins Verbal Learning Test-Revised | Day 1 (day of enrollment) |
| Verbal Learning and Memory | Craft Story Learning & Recall | Day 1 (day of enrollment) |
| Visual Learning and Memory | Brief Visuospatial Memory Test - Revised, Benson Figure Delay | Day 1 (day of enrollment) |
| Visual-Spatial skills | Benson Figure Copy | Day 1 (day of enrollment) |
| Everyday Functioning | Modified Lawton-Brody Instrumental Activities of Daily Living questionnaire | Day 1 (day of enrollment) |
| Diagnosis of MCI/dementia in PD | Objective presence of MCI and dementia in PD will be determined via comprehensive diagnostic criteria | Day 1 (day of enrollment) |
| diabetes mellitus | fasting plasma glucose >126 mg/dL, an HbA1c >6.5%, or use of antihyperglycemic medications | Day 1 (day of enrollment) |
| hypercholesterolemia and dyslipidemia | total cholesterol >240 mg/dL, LDL cholesterol >160 mg/dL, or HDL cholesterol <40 mg/dL or on cholesterol-lowering medication | Day 1 (day of enrollment) |
| hypertension | systolic blood pressure >140 mm Hg, diastolic blood pressure >90 mm Hg, or on antihypertensive medication | Day 1 (day of enrollment) |
| current cigarette smoking | Self-report | Day 1 (day of enrollment) |
| obesity | BMI of >30.0 | Day 1 (day of enrollment) |
| Parkinson's disease severity | Movement Disorders Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) | Day 1 (day of enrollment) |
| Durham |
| North Carolina |
| 27710 |
| United States |
| Background |
| Marquine MJ, Rivera Mindt M, Umlauf A, Suarez P, Kamalyan L, Morlett Paredes A, Yassai-Gonzalez D, Scott TM, Heaton A, Diaz-Santos M, Gooding A, Artiola I Fortuny L, Heaton RK, Cherner M. Introduction to the Neuropsychological Norms for the US-Mexico Border Region in Spanish (NP-NUMBRS) Project. Clin Neuropsychol. 2021 Feb;35(2):227-235. doi: 10.1080/13854046.2020.1751882. Epub 2020 May 20. |
| recruitment flyer - English | View source |
| Research Studies - Parkinson's Disease | View source |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |