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ClinicalTrials.gov ID

NCT07262320

Lead Sponsor

University of Alabama at BirminghamOTHER

Overall Status

Recruiting

Study Type

Observational

Enrollment

1,000Estimated

Last Update Posted

Mar 12, 2026Actual

Start Date

Mar 1, 2026Actual

Primary Completion Date

Mar 31, 2027Estimated

Completion Date

Jun 30, 2027Estimated

Official Title

Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America

Brief Summary

This is an international, multicenter, observational study aimed at investigating acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries. The main questions this study aims to answer are:

• What is the epidemiology, outcomes, and processes of care for patients with AKI-RRT in Latin America?
• How do outcomes differ across different countries in Latin America?
• What factors (demographics, clinical, socioeconomic) influence outcomes in patients with AKI-RRT in Latin America?

The main aims of this study are to:

• Establish a comprehensive database containing clinical, laboratory, treatment, process, and outcome data of patients with AKI-RRT in Latin America
• Describe current epidemiology of AKI-RRT in Latin America
• Compare processes of care and outcomes across different countries in Latin America
• Provide data resources to facilitate and promote clinical research in AKI-RRT

• Dialysis
• Critically Ill Acute Kidney Injury
• Renal Replacement Therapy for Acute Kidney Injury in ICU
• Acute Kidney Injury
• Renal Replacement Therapy
• AKI

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Adult patient (≥18) admitted to the ICU
• First ICU admission during current hospitalization
• Diagnosis of acute kidney injury stage 3 according to KDIGO guidelines
• RRT initiated no earlier than 3 days before or no later than 7 days after ICU admission

Exclusion Criteria:

• Transfer from outside hospital with ongoing RRT
• RRT exposure of less than 2 days (if CRRT or PD was provided) or less than 2 HD/SLED sessions
• Kidney failure (ESRD) patients on maintenance dialysis
• Kidney transplant recipients
• Previous or new diagnosis of glomerulonephritis

Observational Model

Cohort

Time Perspective

Retrospective

Lead Sponsor

University of Alabama at BirminghamOTHER

Collaborators

Vantive Health LLCINDUSTRY

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