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This prospective, randomized controlled trial aims to compare perioperative respiratory changes in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALRP) and open radical prostatectomy (ORP). The primary outcome is the change in peak expiratory flow (PEF) from the preoperative period to the early postoperative (2nd hour) period. Secondary outcomes include PEF recovery at 24 hours, and correlations between PEF change and intraoperative factors such as Trendelenburg angle, pneumoperitoneum duration, and ventilatory parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Open Radical Prostatectomy (Control Group) | Active Comparator | Patients undergoing open radical prostatectomy under standardized general anesthesia. No pneumoperitoneum or steep Trendelenburg position is applied. |
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| Robot-Assisted Laparoscopic Radical Prostatectomy (Study Group) | Experimental | Patients undergoing robot-assisted laparoscopic radical prostatectomy (RALRP) under standardized general anesthesia, with carbon dioxide pneumoperitoneum and Trendelenburg positioning. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgical procedure: Robot-assisted laparoscopic radical prostatectomy | Diagnostic Test | RALRP will be performed with pneumoperitoneum (12-15 mmHg CO₂ insufflation) and 25-30° Trendelenburg position. Peak Expiratory Flow (PEF) will be measured preoperatively, 2 hours postoperatively, and 24 hours postoperatively using the same handheld peak flow meter. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in PEF (L/min) | Difference between preoperative and early postoperative PEF values. | From preoperative baseline to postoperative 2nd hour |
| Measure | Description | Time Frame |
|---|---|---|
| Change in PEF from preoperative to postoperative 24th hour | Evaluates recovery of PEF compared to baseline. | From preoperative measurement (baseline) to postoperative 24th hour |
| Intraoperative parameters correlated with PEF reduction |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| betül aytaç | Ankara Bilkent City Hospital, Department of Anesthesiology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ankara Bilkent City Hospital, Department of Anesthesiology | Ankara | Çankaya | Turkey (Türkiye) |
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Correlation between PEF change and intraoperative variables including Trendelenburg angle/duration, pneumoperitoneum pressure/duration, ventilatory pressures, and intraoperative fluid balance.
| From induction of anesthesia to end of surgery |
| Incidence of respiratory complications | Frequency of postoperative respiratory events such as desaturation, need for reintubation, or presence of chemosis. | Within the first 24 hours after surgery |
| ID | Term |
|---|---|
| D011471 | Prostatic Neoplasms |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
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