The goal of this clinical trial is to evaluate how manual dominance influences the effectiveness of bilateral robotic treatment in right-handed patients with chronic stroke.

Researchers will compare the outcome of a bilateral robotic treatment for the upper limbs in left vs right hemisphere lesions following stroke.

Participants will:

• perform a bilateral robotic treatment for the upper limb (15 sessions in three weeks) followed by 20-minutes standard manual rehabilitative sessions
• be evaluated before and after treatment with clinical scales, resting- state EEG and kinematic measurements

Inclusion Criteria:

• Subjects aged between 18 and 80 years, of either sex
• Subjects able to understand and provide, or have provided on their behalf, informed consent
• History of a single unilateral ischemic or hemorrhagic cerebrovascular event in the chronic phase (> 6 months)
• Subjects with mild to moderate functional impairment of the right or left upper limb (ability to perform antigravity active movements)

Exclusion Criteria:

• Subjects with cognitive deficits that impair understanding of the required tasks (MMSE score corrected for age and education < 24/30)
• Subjects with severe visual deficits
• Subjects with upper limb spasticity preventing the use of robotic devices (spasticity measured using the Modified Ashworth Scale > 3)
• Inability or unwillingness to provide informed consent
• Left-handed subjects

all IPD that underlie results in a publication