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Acute myocardial infarction (AMI) remains a leading cause of mortality worldwide. Although early revascularization has markedly improved short-term outcomes, the incidence of major adverse cardiovascular events after the index event remains unacceptably high, posing a formidable clinical challenge. Contemporary risk-stratification instruments rely predominantly on a restricted set of conventional clinical variables and therefore fail to capture the full spectrum of individual pathophysiological complexity. To overcome these limitations, the present investigation aims to develop a post-AMI prognostic model that integrates comprehensive multimodal data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MI group | Patients who present with myocardial infarction and undergo successful percutaneous coronary intervention will be eligible for enrollment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Percutaneous coronary intervention | Procedure | Percutaneous coronary intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recurrent myocardial infarction or cardiac death | Patients received recurrent myocardial infarction or cardiac death | At 24-month Follow-up |
| Diagnostic performance | Diagnostic performance of the AI-driven multimodal predictive model: area under the receiver-operating characteristic curve (AUC), sensitivity, specificity, overall accuracy, positive predictive value (PPV), and negative predictive value (NPV). | At 24-month follow-up |
| MACE at 24 months | Major adverse cardiovascular events, defined as a compisite of cardiac death, myocardial infarction, target vessel revascularization. | At 24-month follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| MACE at 60 months | Major adverse cardiovascular events, defined as a compisite of cardiac death, myocardial infarction, target vessel revascularization. | At 60-month follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| MACE according to pre-specified subgroups | MACE stratified by sex, diabetes status, and chronic kidney disease (CKD) status. | At 24- and 60-month follow-up |
| MACE according to physiological status | MACE prediction integrating physiological metrics-angiographic FFR, IMR, MRR, and CFR-of the culprit and non-culprit coronary arteries. |
Inclusion Criteria:
Exclusion Criteria:
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Patients with myocardial infarction
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jun Jiang, MD | Contact | +86 15657125311 | 21918219@zju.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Second Affiliated Hospital of Zhejiang University School of Medicine | Hangzhou | Zhejiang | 310009 | China |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D062645 | Percutaneous Coronary Intervention |
| ID | Term |
|---|---|
| D057510 | Endovascular Procedures |
| D014656 | Vascular Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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| At 24- and 60-month follow-up |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D019060 | Minimally Invasive Surgical Procedures |