COPD is a preventable and treatable lung disease characterized by persistent and progressive airflow limitation. PRISm, on the other hand, is a spirometry pattern that does not meet COPD diagnostic criteria despite symptoms and functional impairments, but requires maintenance. PRISm can predispose to the development of COPD and exacerbations, and can reduce exercise capacity by reducing respiratory function and oxygen consumption. There are no studies in the literature comparing respiratory muscle strength, peripheral muscle strength, and oxygenation in PRISm, COPD, and healthy individuals. Therefore, this study aimed to evaluate these parameters and compare them with healthy individuals.

Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable multisystem lung disease characterized by chronic respiratory symptoms (dyspnea, cough, sputum production, and/or exacerbations) due to airway abnormalities, causing persistent and often progressive airflow limitation. PRISm is defined as a spirometry pattern that is not always a stable phenotype but should be considered "sick" because symptoms and/or functional and/or structural abnormalities are present and therefore require care and treatment. Recently, PRISm has been identified as a subtype more prone to developing COPD or experiencing acute exacerbations. In addition to affecting the respiratory muscles, PRISm's effects on respiratory function lead to decreased body oxygen consumption and increased dyspnea. PRISm can also lead to decreased exercise capacity due to the respiratory problems and dyspnea it causes. Although there are not enough studies in the literature investigating exercise capacity and lung functions on behalf of PRISm, no previous study comparing respiratory muscle strength, peripheral muscle strength and oxygenation in PRISm, COPD and healthy individuals has been found.

Inclusion Criteria:

For the COPD group:

• Being >40 years old,
• Being diagnosed with COPD,
• Being clinically stable,
• Volunteering to participate in the study.

For the PRISm group:

• Being >40 years old,
• Being diagnosed with PRISm,
• Volunteering to participate in the study.

For the healthy control group:

• Being >40 years old,
• Volunteering to participate in the study.

Exclusion Criteria:

For the COPD group:

• Having severe orthopedic, neurological, or cardiac diseases,
• Being in a COPD exacerbation,
• Having a comorbid lung disease,
• Being on clinically unstable medication,
• Voluntarily not participating in the study.

For the PRISm group:

• Being diagnosed with COPD,
• Having severe orthopedic, neurological, or cardiac diseases,
• Having a comorbid lung disease,
• Voluntarily not participating in the study.

For the healthy control group:

• Having a known chronic disease,
• Voluntarily not participating in the study.

Patients with COPD and PRSIm will be included and compared with healthy controls