This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients.

To achieve this task the main goals of this study will be:

• to standardize and optimize qMRI protocols (acquisition time, sensitivity)
• to acquire ranges of normative values of qMRI parameters as a function of age and sex at high fields (3 Tesla) and ultra-high fields (UHF for ultra-high field, 7 Tesla)
• To develop integrated tools for image processing and the generation of normative models of the healthy brain normative values
• To assess the clinical feasibility and the multicenter validation of the multiparametric tools proposed in the case of application to MS.

Inclusion Criteria:

• For healthy volunteers :

  • Male or female aged 20 to 50
  • Subject with no history of previous or concomitant neurological and psychiatric diseases at the time of inclusion
  • Subject without a history of traumatic brain injury
  • Subject with no vascular history (arterial hypertension, stroke) or concomitant at the time of its inclusion
  • Subject has no history of chronic drug and/or alcohol abuse
  • Subject having received information regarding the study and having signed an informed consent
  • Beneficiary or entitled person to a social security scheme

• For MS patients

  • Male or female aged 18 to 52
  • Patient diagnosed with MS according to the
  • criteria of McDonald 2017
  • Patient presenting a maximum EDSS of 6
  • Patient with MS for less than 10 years of evolution
  • Patient having received information regarding the study and having signed an informed consent
  • Patient beneficiary or entitled to a plan of social security

Exclusion Criteria:

• For healthy subjects :

  • Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia.
  • Subject unable to maintain a supine position for a prolonged period
  • Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form
  • Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman)

• For MS patients

  • Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia.
  • Subject unable to maintain a supine position for a prolonged period
  • Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form
  • Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman)