Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps

Effect of Full-House Endoscopic Sinus Surgery With Versus Without Nasopharyngeal Lymphoid Ablation on Local Mucosal Inflammation in Chronic Rhinosinusitis With Nasal Polyps

This study is designed to evaluate whether the addition of nasopharyngeal lymphoid tissue ablation to full-house endoscopic sinus surgery (ESS) provides superior control of nasal mucosa inflammation compared to full-house ESS alone in patients with nasal polyps. Thirty-two adult participants will be randomly assigned to undergo either full-house ESS only or full-house ESS combined with nasopharyngeal lymphoid tissue ablation. The primary outcome will be assessed through changes in inflammatory cell profiles at 1, 3, and 6 months postoperatively. Secondary outcomes include inflammatory cytokine levels, symptom scores, endoscopic findings, polyp recurrence rates, and safety measures.

Inclusion Criteria:

• Aged 18-65 years
• Diagnosed with CRSwNP according to EPOS criteria
• Blood eosinophil count > 0.3 × 10⁹/L

Exclusion Criteria:

• Pregnant or lactating women.
• Cystic fibrosis
• primary ciliary dyskinesia
• fungal ball rhinosinusitis
• systemic vasculitis or granulomatous disease
• malignancy
• immunodeficiency.
• Subjects with an upper-respiratory-tract infection within the past 4 weeks.
• Clinically significant metabolic, cardiovascular, immune, neurologic, hematologic, gastrointestinal, cerebrovascular, or respiratory disorders, or any condition that, in the investigator's opinion, could interfere with outcome assessment or compromise patient safety.
• Currently participating in another clinical trial or having participated in one within 30 days, or staff directly involved in this study.