Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
By integrating retrospective multimodal data such as pathology and imaging, AI technologies offer novel solutions for disease classification, tumor grading, histological and molecular subtyping, selection of chemotherapy regimens, risk stratification, and treatment-response prediction. This research direction not only deepens our understanding of tumor biological characteristics but also provides essential support for precision medicine and individualized therapy. It holds significant theoretical and practical value and has important implications for mitigating strained medical resources and improving the accuracy of therapeutic decision-making, representing a cutting-edge application with substantial translational potential.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| QFSH external validation dataset | 1000 slides from 1000 eligible individuals were obtained in the Qianfoshan Hospital (QFSH, Jinan, China) between January 2020 and July 2025, which was used to validate the pathology foundation models. | ||
| NFH dataset | We conducted a validation study to compare the diagnostic performance among pathologists, our pathology foundation model, and pathologist-with-AI-assisted diagnosis. This study was initiated at Nanfang Hospital, Southern Medical University (NFHSMU), with patient enrollment from January 1, 2011 to July 31, 2024. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Area under ROC curve (AUC) | Area under the curve | Diagnostic evaluation will be performed within 1 week when the WSIs are obtained |
| Measure | Description | Time Frame |
|---|---|---|
| Specificity | The true negative rate (TNR) of the diagnostic platform, which is the ratio between the number of negative individuals correctly categorized by platform and the total number of actual negative individuals (%). | Diagnostic evaluation will be performed within 1 week when the WSIs are obtained |
| Sensitivity |
Not provided
Inclusion Criteria:
Exclusion Criteria:
1.Patients with missing data or specimens not meeting quality control requirements for analysis.
Not provided
Not provided
Inclusion criteria comprised patients aged 18-75 years with definitive pathological diagnoses. All cases were retrospectively collected from Nanfang Hospital, Southern Medical University (NFHSMU) .
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Li Liang | Nanfang Hospital, Southern Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanfang Hospital, Southern Medical University | Guangzhou | Guangdong | 510515 | China | ||
| Qianfoshan Hospital |
Requests for the data collected and analyzed in this study will be considered if the application is in line with public benefits and the applicant is willing to sign a data access agreement. Contact can be through the corresponding author.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Samples Without DNA: Samples retained, with no potential for DNA extraction from any retained samples (e.g., fixed tissue, plasma)
The true positive rate (TPR) of the diagnostic platform, which is the ratio between the number of positive individuals correctly categorized by platform and the total number of actual positive individuals (%). |
| Diagnostic evaluation will be performed within 1 week when the WSIs are obtained |
| Jinan |
| Shandong |
| 250014 |
| China |