The purpose of this study is to evaluate the safety and tolerability of two new artificial tear formulations in subjects with moderate dry eye disease.

Each subject will receive 2 investigational products (one drop per eye of each investigational product) in a cross-over study design according to a randomization schedule. Individual duration of participation will be approximately 21 days.

Inclusion Criteria:

• Subject must be willing and able to understand and sign an ethics committee approved informed consent form.
• Subject must be willing and able to attend all study visits as required by the protocol.
• Subject must exhibit symptoms of dry eye at the Screening Visit.
• Subject must currently use artificial tears.
• Other protocol-defined inclusion criteria may apply.

Exclusion Criteria:

• Has any known active ocular disease and/or infection.
• Has any known infection or inflammation that requires treatment or has a systemic condition that, in the opinion of the investigator, may affect a study outcome variable.
• Any ocular injury to either eye in the 12 weeks prior to screening.
• Current wearer of contact lenses or has a history of contact lens wear within the previous 1 month.
• Other protocol-defined exclusion criteria may apply.