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| ID | Type | Description | Link |
|---|---|---|---|
| x | Other Grant/Funding Number | The Swedish Research Council |
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| Name | Class |
|---|---|
| University Hospital, Umeå | OTHER |
| University of Eastern Finland | OTHER |
| Czech Academy of Sciences | OTHER |
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The goal of this study is to study the effect exposure to air pollution and its effect on development of dementia.
Does the diesel exhaust change the function of the olfactory system?
Have the exposures measurable effects on the sense of smell and cognitive ability?
Forty people are exposed to diesel exhaust exhaust and filtered air. The exposures are blinded and in a randomized order. Both groups undergo biopsies of the olfactory epithelium in the nose under local anesthesia after the exposures and after performing cognitive test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exposure to diesel exhaust | Active Comparator | The participants will be exposed in an exposure chamber for diesel exhaust in a concentration of 300 µg/m³ for one hour. |
|
| Exposure to filtered air | Placebo Comparator | The participants will be exposed in an exposure chamber to filtered air for one hour. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diesel Exhaust Particles | Other | During exposure to diesel exhaust, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale. |
| Measure | Description | Time Frame |
|---|---|---|
| Diesel exhaust causes cellular dysfunction of the olfactory system | RNA sequencing and DNA methylation will be conducted to identify biomarkers for acute exposure to diesel exhaust. | 3 years. |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive test | Olfactory function well be evaluated by using "sniffin' sticks," and a Letter-Digit Substitution Test as a marker for cognitive processing speed. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Umeå Univeristy | Umeå | 90185 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35010571 | Background | Martikainen MV, Aakko-Saksa P, van den Broek L, Cassee FR, Carare RO, Chew S, Dinnyes A, Giugno R, Kanninen KM, Malm T, Muala A, Nedergaard M, Oudin A, Oyola P, Pfeiffer TV, Ronkko T, Saarikoski S, Sandstrom T, Schins RPF, Topinka J, Yang M, Zeng X, Westerink RHS, Jalava PI. TUBE Project: Transport-Derived Ultrafines and the Brain Effects. Int J Environ Res Public Health. 2021 Dec 28;19(1):311. doi: 10.3390/ijerph19010311. |
| Label | URL |
|---|---|
| ADAIR website | View source |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jun 17, 2021 | Aug 18, 2025 | Prot_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 17, 2021 | Aug 18, 2025 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Filtered air | Other | During exposure to filtered air, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale |
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| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |