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This retrospective cohort study analyzes risk factors for central visual loss (CVL) after severe-stage glaucoma surgery. The primary hypothesis is that 1) visual prognosis is determined primarily by early postoperative intraocular pressure (IOP) stability rather than surgical choice, and 2) the nature of risk (hypotony vs hypertension) is modified by baseline visual reserve. We analyzed outcomes in 523 patients with severe-stage glaucoma who underwent trabeculectomy or Ahmed glaucoma valve (AGV) implantation, focusing on the dichotomous risk profile stratified by baseline visual acuity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | 231 eyes that underwent trabeculectomy for severe-stage glaucoma | ||
| Group 2 | 292 eyes that underwent Ahmed glaucoma valve implantation for severe-stage glaucoma |
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| Measure | Description | Time Frame |
|---|---|---|
| Central Visual Loss (CVL) at 3 months postoperatively | Central visual loss defined as any of the following at 3 months postoperatively: (i) best-corrected visual acuity (BCVA) ≤ 20/200; (ii) decrease of ≥ 4 Snellen lines from baseline; or (iii) further deterioration of BCVA in eyes with preoperative BCVA ≤ 20/200. | At 3 months postoperatively |
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Inclusion Criteria:
1. Patients who underwent trabeculectomy or Ahmed glaucoma valve implantation at Yonsei Medical Center between January 2005 and October 2024.
2. Glaucoma patients who underwent static quantitative perimetry (visual field test) before and after surgery.
3. Patients with a preoperative Mean Deviation (MD) of ≤ -20 dB.
Exclusion Criteria:
1. Patients who were unable to undergo visual field testing due to poor preoperative visual acuity.
2. Patients with central visual field defects caused by retinal or neurological diseases other than glaucoma.
3. Patients with false-positive or false-negative responses ≥33% on visual field testing.
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Patients with severe-stage glaucoma who underwent trabeculectomy or Ahmed glaucoma valve implantation at Gangnam Severance Hospital, Yonsei University College of Medicine, between January 2005 and October 2023, with at least 1-year follow-up data available.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gangnam Severacne Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16386972 | Background | Mills RP, Budenz DL, Lee PP, Noecker RJ, Walt JG, Siegartel LR, Evans SJ, Doyle JJ. Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease. Am J Ophthalmol. 2006 Jan;141(1):24-30. doi: 10.1016/j.ajo.2005.07.044. | |
| 25706956 | Background | Bai J, Smock SL, Jackson GR Jr, MacIsaac KD, Huang Y, Mankus C, Oldach J, Roberts B, Ma YL, Klappenbach JA, Crackower MA, Alves SE, Hayden PJ. Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus. PLoS One. 2015 Feb 23;10(2):e0118286. doi: 10.1371/journal.pone.0118286. eCollection 2015. |
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| 25811763 | Background | Zhu S, Li ZW, Zhao H. Patchy micelles based on coassembly of block copolymer chains and block copolymer brushes on silica particles. Langmuir. 2015 Apr 14;31(14):4129-36. doi: 10.1021/acs.langmuir.5b00526. Epub 2015 Apr 1. |
| 17617176 | Background | Pernas M, Garcia-Casado G, Rojo E, Solano R, Sanchez-Serrano JJ. A protein phosphatase 2A catalytic subunit is a negative regulator of abscisic acid signalling. Plant J. 2007 Sep;51(5):763-78. doi: 10.1111/j.1365-313X.2007.03179.x. Epub 2007 Jul 7. |
| 21825181 | Background | Lambiase A, Micera A, Sacchetti M, Cortes M, Mantelli F, Bonini S. Alterations of tear neuromediators in dry eye disease. Arch Ophthalmol. 2011 Aug;129(8):981-6. doi: 10.1001/archophthalmol.2011.200. |