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In this study, patients receiving Eylea treatment will be treated with Yesafili, a biosimilar molecule, and routine examination results will be noted.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients treated with Yesafili | aflibercept biosimilar used |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aflibercept biosimilar (MY-1701P) | Drug | Patients receiving the aflibercept biosimilar MY-1701P (marketed as Yesafili®) as part of routine clinical care. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Best-Corrected Visual Acuity (BCVA) and Central Macular Thickness After MY-1701P Injection | Evaluation of anatomical and functional outcomes following intravitreal MY-1701P (aflibercept biosimilar) treatment, including presence or resolution of intraretinal and subretinal fluid, changes in central macular thickness, and improvement in best-corrected visual acuity (BCVA) measured by standardized ETDRS (Early Treatment Diabetic Retinopathy Study) or Snellen methods. | Baseline to Month 6 |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of MY-1701P on Pigment Epithelial Detachment, Neovascularization Size, and Treatment Interval Adjustment | Assessment of the influence of MY-1701P treatment on pigment epithelial detachment (PED) height and area, macular neovascularization size, and changes in treatment intervals over the follow-up period, based on optical coherence tomography (OCT) and fluorescein angiography findings. | Baseline to Month 6 |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged 45 to 90 years diagnosed with active neovascular (exudative) age-related macular degeneration (nAMD), who are receiving routine ophthalmologic follow-up at a tertiary referral center and have been clinically indicated for intravitreal aflibercept biosimilar (MY-1701P) injection. Participants will be selected based on evidence of disease activity on ophthalmologic examination and optical coherence tomography (OCT) imaging.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sinan Kalpakoğlu, M.D. | Contact | +905380518244 | sinankalpakoglu17@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prof. Dr. Cemil Taşcıoğlu City Hospital | Recruiting | Istanbul | şişli | 34384 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| ID | Term |
|---|---|
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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