A RCT of Moist Ag Dressing in Chronic Wound

Dry Versus Moist Ag Dressings for Local Wound Infections: A Randomized Controlled Trial on Effectiveness and Cost-Effectiveness

This study aims to explore the differences in efficacy and cost-effectiveness between self-adhesive soft polysilicone silver ion foam dressings and traditional silver dressings in local infected wounds through a prospective randomized controlled study. The goal is to provide evidence-based medical support for clinical application, further shorten the wound healing time, and reduce the economic burden on the medical system and patients.

Inclusion Criteria:

1. The patient's age ranges from 18 to 80 years old.
2. According to the IWII wound infection staging, infected wounds are classified as local infections*.
3. The wound type is ulcer, with an ulcer area ranging from 1 to 40 cm².
4. The wound stage is in the necrosis stabilization phase, granulation growth phase, or epithelial crawling phase**.
5. Voluntary participation in this study and signing the informed consent form

Exclusion Criteria:

1. Severe diseases such as acute myocardial infarction, heart failure, hepatitis, shock, and respiratory failure have not been corrected yet;
2. The blood sugar level of diabetes is out of control, with fasting blood sugar > 15 mmol/L and glycosylated hemoglobin ≥ 10%;
3. There is active bleeding in the wound, and the conventional basic treatment plan cannot be implemented;
4. Serum albumin < 20 g/L; hemoglobin < 60 g/L; platelets < 50 × 109/L;
5. Disseminated infection or systemic infection state, and antibiotics are being used or will be used for treatment;
6. Patients with advanced malignant tumors;
7. The patient is in the active stage of autoimmune diseases;
8. The patient has previously been allergic to self-adhesive soft polysilicone silver ion foam dressings (Meipikang Silver) or Anxidean Nano Silver Trauma Patch;
9. The patient cannot cooperate or has a mental disorder;
10. According to the investigator's judgment, the subject has clear reasons that affect wound healing and is not suitable for this study or cannot comply with the requirements of this study.