Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients

Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients

The study is designed to diminish intra-dialytic hypertension in chrnic hemodialysis patients suffering from metabolic acidosis (low bicarbonate levels). The intervention is a tab of 500 mg sodium bicarbonate twice a day for one month, vs. placebo.

Inclusion Criteria:

• Chronic hemodialysis patient > 3 months
• 3 dialysis per week, KTV>1.2
• capable of informed concent.
• rise in blood pressure during hemodialysis > 10 mm Hg, for at least 50% of dialysis sessions in the month prior to inclusion.
• Normal volume status, by clinical physician assessment + bioimpedance

Exclusion Criteria:

• age under 18,
• pregnancy
• unable to sign informed concent
• planned for kidney transplant in the following 3 month.
• congestive heart failure (NYHA 3-4)
• hospitalization for acute MI or CHF in the past 3 months.
• low compliece to medical therapy
• regular pre-dialysis tests with bicarbonate > 24 in the past 3 months