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Electrical stimulation (DBS) through electrodes implanted in the dentate nucleus of the cerebellum for the treatment of tremor intractable with medication, dystonia due to cerebrovascular disease (stroke), sequelae of traumatic brain injury, and ataxia (a disease that causes incoordination of movements). Use of advanced magnetic resonance imaging techniques and recording of nerve cell activity in this nucleus
To establish anatomical and functional criteria, based on stereotactic imaging and electrophysiological recordings, that enable the precise implantation of electrodes in the DN and its efferent projections for the treatment of movement disorders. This study aims to describe a surgical technique for the implantation of deep brain electrodes targeting the stimulation (DBS) of the dentate nucleus (DN) and its efferent projections, supported by the magnetic resonance imaging (MRI), the diffusion tensor imaging (DTI), reformatted in the stereotomographic images and related to stereotactic landmarks and checked with semimicro deep brain recording.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Final Stereotactics coordinates in DN-DBS | Computational dataset |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Analytical observation | Other | Analysts observation; CT + MRI + DTI pre and post operative stereotactic coordinates - implants DBS in DN |
|
| Measure | Description | Time Frame |
|---|---|---|
| DSB in the dentate nucleus | All stereotactic image calculations the definitive location of the implants in relation to the targets proposed in the ND, were reanalyzed in a digital environment that included co-registration of the preoperative MRI, DTI, and stereotomograph | From enrollment to the end of treatment at 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with dystonia, ataxia or tremor
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34513166 | Result | Diniz JM, Cury RG, Iglesio RF, Lepski GA, Franca CC, Barbosa ER, de Andrade DC, Teixeira MJ, Duarte KP. Dentate nucleus deep brain stimulation: Technical note of a novel methodology assisted by tractography. Surg Neurol Int. 2021 Aug 9;12:400. doi: 10.25259/SNI_338_2021. eCollection 2021. |
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There are other projects similar to this one underway. I'd like to be able to connect with other researchers and share our challenges and findings.
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| ID | Term |
|---|---|
| D020821 | Dystonic Disorders |
| D020329 | Essential Tremor |
| D002819 | Chorea |
| D004421 | Dystonia |
| D001259 | Ataxia |
| ID | Term |
|---|---|
| D009069 | Movement Disorders |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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