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The goal of our work is to to compare the effect of preemptive Ketamine administration versus superficial cervical plexus block on the incidence of postoperative neuropathic pain in patients undergoing thyroidectomy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BCS Group | Active Comparator | Patients received a bilateral ultrasound-guided superficial cervical plexus block after induction (Ropivacaine 0.2%,with a volume of 10 mL administered to each side) |
|
| KETA group | Active Comparator | Patients received intravenous ketamine (0.25 mg/kg bolus followed by a 2 µg/kg/min infusion). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketamine perfusion | Drug | Intravenous ketamine 0.25 mg/kg bolus followed by a 2 µg/kg/min infusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of chronic neuropathic pain at three months | The incidence of chronic neuropathic pain at three months after thyroidectomy, as determined by the DN4 questionnaire. | three months after thyroidectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Twenty-four hour postoperative rescue analgesia requirements | The total amount of extra, on-demand pain medication a patient needed in the first 24 hours after their surgery was completed. | within the first 24 hours after the thyroidectomy. |
| Intraoperative sufentanil consumption |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ibtissem BEN TALEB | University of Tunis El Manar, Anesthesia and critical care department, Taher Maamouri University Hospital, | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mohamed Taher Maamouri University Hospital | Nabeul | Nabeul Governorate | 8000 | Tunisia |
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| ID | Term |
|---|---|
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Superficial cervical plexus block | Procedure | Bilateral ultrasound-guided superficial cervical plexus block after induction(Ropivacaine 0.2% Ropivacaine 0.2%, with a volume of 10 mL administered to each side) was performed for patients of this group |
|
The secondary endpoints included intraoperative sufentanil consumption and reinjection requirements. |
| During the intraoperative period |
| Postoperative sleep quality | Sleep quality was assessed 24 hours postoperatively to accurately reflect the effects of analgesia, utilizing the Athens Insomnia Scale (AIS) score. | During the first 24 postoperative hours. |
| Incidence of postoperative nausea and vomiting (PONV) within 24 hours post-surgery | Occurrence of at least one episode of nausea or vomiting within the first 24 hours after surgery. | 24 hours after surgery. |
| The Observer's Assessment of Alertness/Sedation (OAA/S) within a 2-hour timeframe following thyroidectomy. | Patients underwent Observer's Assessment of Alertness/Sedation (OAA/S) assessment within a 2-hour timeframe following thyroidectomy, before being cleared for PACU discharge. | 2-hour timeframe following thyroidectomy |