A Trial of SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure

A Double-Blind, Randomized, Dose-Escalating Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Dose SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure

This is a clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamic and immunogenicity of single subcutaneous injection of SHR-4658 in healthy volunteers and volunteers with elevated blood pressure.

Inclusion Criteria:

1. Able and willing to provide a written informed consent.
2. Blood pressure as defined in the protocol.
3. Male or female，aged 18 to 55 years (inclusive).
4. Meet the weight standard.

Exclusion Criteria:

1. Known history or current clinically significant disease.
2. Protocol-defined risk factors for disease.
3. Participated in clinical trials of other drugs or medical devices.
4. Pregnant or nursing women.