Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion. Patients will receive either 0.5% bupivacaine plus liposomal bupivacaine or 0.5% plain bupivacaine. Outcomes include opioid consumption over 72 hours, pain scores, length of stay, and time to ambulation.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ESP + Liposomal Bupivacaine | Experimental | Group 1 receives ESP block with 0.5% bupivacaine plus liposomal bupivacaine. |
|
| ESP + Plain Bupivacaine | Experimental | Group 2 receives ESP block with 0.5% plain bupivacaine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ESP Block with Bupivacaine | Drug | Cervical and lumbar ESP blocks performed under ultrasound guidance using plain bupivacaine. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Pain as measured by opiate consumption | Morphine MilliEquivalents | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Pain at rest and with movement as measured by patient reported pain scores | Numeric Rating Scale (0-10) 0 being no pain, 10 being worst pain imaginable | 4, 8, 12, 24, 48, and 72 hours |
| Discharge Readiness |
Not provided
Inclusion Criteria
Exclusion Criteria
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Stephen Davies | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke University | Durham | North Carolina | 27710 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
Not provided
Not provided
| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ESP Block with Bupivacaine + Liposomal Bupivacaine | Drug | Cervical and lumbar ESP blocks performed under ultrasound guidance using bupivacaine admixed with liposomal bupivacaine. |
|
Hospital and PACU Length of Stay
| 72 hours |
| Postoperative Pain Severity as measured by required time for patient controlled-analgesia | Duration of patient controlled analgesia use | 72 hours |
| Incidents of post-operative nausea and vomiting | Post-operative Nausea and Vomiting | 72 hours |
| Time to first ambulation | 72 hours |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D000588 |
| Amines |