AN INTERVENTIONAL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PF-08634404 MONOTHERAPY AND IN COMBINATION WITH OTHER ANTICANCER AGENTS IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA
AN INTERVENTIONAL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PF-08634404 MONOTHERAPY AND IN COMBINATION WITH OTHER ANTICANCER AGENTS IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA
This study is testing a new medicine called PF-08634404 and how it works in adults with advanced Renal Cell Carcinoma (RCC)- a type of kidney cancer that is either locally advanced (spread to nearby tissues) or metastatic (spread to other parts of the body). The study will look at the safety of the study medicine, when given alone or with other anticancer medicines, and how this type of cancer responds to them.
To join the study, participants must be adults; with locally advanced or metastatic RCC; who have not received treatment for their advanced kidney cancer.
Participants will receive study medicine either alone or with other anticancer medicines. The medicine will be given through intravenous (IV) infusions, which means it will be injected directly into a vein. All treatments will take place at clinical study sites, where trained medical staff will take care of participants during and after each visit.
Inclusion Criteria:
Exclusion Criteria:
Participants may be excluded if they meet any of the following:
ClinicalTrials.gov_Inquiries@pfizer.com1-800-718-1021
Duarte, California 91010, United States
La Jolla, California 92037, United States
La Jolla, California 92037, United States
La Jolla, California 92037, United States
San Diego, California 92101, United States
San Diego, California 92103, United States
San Diego, California 92127, United States
Orlando, Florida 32806, United States
Boston, Massachusetts 02215, United States
Rochester, Minnesota 55902, United States
Clifton Park, New York 12065, United States
Long Island City, New York 11101, United States
New York, New York 10065, United States
New York, New York 10065, United States
Chattanooga, Tennessee 37404, United States
Chattanooga, Tennessee 37404, United States
Chattanooga, Tennessee 37404, United States
Nashville, Tennessee 37203, United States
Nashville, Tennessee 37203, United States
Conroe, Texas 77384, United States
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League City, Texas 77573, United States
Sugar Land, Texas 77478, United States
Blacksburg, Virginia 24060, United States
Low Moor, Virginia 24457, United States
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Wuhan, Hubei 430022, China
Nanjing, Jiangsu 210000, China
Dresden, Saxony 01307, Germany
Shinjuku-ku, Tokyo 1608582, Japan