Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.

Primary Objectives

• To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care

Secondary Objectives

• To determine changes in health-related quality of life changes following ultrasound-guided nsPFA
• To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA.
• To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.

Eligibility Criteria

• Scheduled to undergo ultrasound guided nsPFA as standard of care

• Age 18 to 80 years.

• Capable of providing independent consent.

• Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:

  • Benign FNA X 2 or
  • Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
  • Benign FNA X 1 and radiographic/laboratory evidence of functional nature

• Nodule measuring >2cm in greatest dimension

• Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)

• No abnormal cervical lymph nodes during screening visit .

Exclusion Criteria

• Age <18
• Patients considered unsuitable for nsPFA by the treating physician