This study assesses the impact of cannabis (also commonly called marijuana, weed, or THC) use on quality of life among patients with multiple myeloma who are receiving chemotherapy. It also evaluates the potential benefits and harms of cannabis use.

PRIMARY OBJECTIVES:

I. Characterize and compare longitudinal patterns in quality of life, as assessed by the Functional Assessment of Cancer Therapy-Multiple Myeloma (FACT-MM) instrument, among cannabis users and non-users.

II. Estimate and characterize the potential therapeutic benefit and adverse effects associated with cannabis use as assessed by longitudinal patterns of patient reported symptoms (Edmonton Symptoms Assessment Scale-ESAS) and medical assessments (Common Terminology Criteria for Adverse Events-CTCAE v5.0) through a comparative analysis of users and non-users.

OUTLINE: This is an observational study. Participants are assigned to 1 of 2 groups.

GROUP I: Patients complete surveys and undergo blood sample collection throughout the study.

GROUP II: Healthcare providers complete a survey on study.

Inclusion Criteria:

• * Documented informed consent of the participant

  • Age: ≥ 18 years
  • ECOG ≤ 3
  • Ability to read and understand English
  • Patient must be newly diagnosed with a histologically confirmed multiple myeloma
  • Patients may have started first line therapies and received up to four cycles
  • HCP SURVEY: Documented informed consent of the participant
  • HCP SURVEY: Age: ≥ 18 years
  • HCP SURVEY: Licensed physician, physician assistant, nurse practitioner, or registered nurse
  • HCP SURVEY: Currently practicing in oncology or providing direct care to oncology patients
  • HCP SURVEY: Able to read and understand English
  • HCP SURVEY: Affiliation with City of Hope

Exclusion Criteria:

• * Patients may not have completed five cycles of first line therapy or undergone any second line therapy

  • Other active malignancy
  • Patients may not have undergone autologous hematopoietic stem cell transplantation
  • Unable to comply with the study assessments
  • HCP SURVEY: Reports directly to study PI (Dr. Richard Lee)
  • HCP SURVEY: Member of the study team or involved in survey design or analysis
  • HCP SURVEY: Individuals with a real or perceived conflict of interest that could bias survey responses

Newly diagnosed multiple myeloma patients who have received up to four cycles of first line therapy and City of Hope affiliated health care providers currently practicing in oncology or providing direct care to oncology patients.