This is a single-center, double-arm, patient masked, randomized controlled trial. Subjects will be enrolled in the Emergency Department at the Penn State Milton S. Hershey Medical Center. Eligible subjects must present to the ED and be diagnosed with a traumatic corneal abrasion. One eye from each patient will be considered the study eye.

Inclusion Criteria

• Each of the following criteria must be met for study participation:

  1. Male or female, age 18 or older at the time of study enrollment.

  2. Corneal abrasion in one eye.

  3. Willingness to sign the IRB-approved informed consent form (ICF) for study participation.

  4. Availability, willingness, and sufficient cognitive awareness to return for study-required visits and comply with examination procedures.

     Exclusion Criteria:

     Patient candidates presenting any of the following characteristics will not be eligible for study participation:

  1. Corneal abrasion in both eyes.
  2. Allergy to moxifloxacin or other fluoroquinolone antibiotics.
  3. Allergy to ibuprofen or other non-steroidal anti-inflammatory drugs.
  4. History of neurotrophic cornea for any reason, in the study eye.
  5. History of medical conditions known to cause decreased corneal sensation in the study eye including but not limited to HSV, HZO, and diabetes.
  6. History of extraocular surgical procedures known to cause decreased corneal sensation in the study eye, including but not limited to trigeminal nerve clamp.
  7. Any anterior segment pathology in the study eye that could significantly affect corneal wound healing (e.g. aniridia, clinically significant corneal dystrophies [ABMD], etc.)
  8. Any visually significant intraocular media opacity other than corneal abrasion in the study eye (as determined by the investigator). Such opacities might include corneal scar or vitreous hemorrhage.
  9. History of any clinically significant retinal pathology or ocular diagnosis in the study eye that could, in the investigator's best judgement, alter or limit visual acuity (e.g. ischemic disease, macular degeneration, retinal detachment, optic neuropathy, amblyopia, strabismus, aniridia, epiretinal membrane, etc.).
  10. History of uveitis in either eye.
  11. History of intraocular or corneal surgery in the study eye besides laser peripheral iridotomy (LPI), retinal barrier laser.
  12. Current ocular infection in the study eye.
  13. Presence of uncontrolled systemic disease that could limit capacity to sign consent or comply with treatment schedule (e.g. mental illness, dementia, etc.).
  14. Unsuitable for study participation for any other reason, as determined by the Investigator's clinical judgement