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| ID | Type | Description | Link |
|---|---|---|---|
| 5P20GM148302 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of General Medical Sciences (NIGMS) | NIH |
| COBRE in Neurodevelopment and its Disorders (CNDD) | UNKNOWN |
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This study investigates the safety and potential efficacy of personalized, image-guided low intensity focused ultrasound (LIFU) targeting the thalamus in individuals with Autism Spectrum Disorder (ASD). The study evaluates behavioral, neuroimaging, and electrophysiological outcomes following LIFU stimulation using a non-invasive device.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active LIFU | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active LIFU | Device | In this open label study, all participants will receive active LIFU |
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| Measure | Description | Time Frame |
|---|---|---|
| Social Responsiveness Scale, Second Edition (SRS-2) | Baseline (Visit 1) to post-stimulation (Visit 7, within 1 week of last stimulation; Visit 8, within 1 month of last stimulation) |
| Measure | Description | Time Frame |
|---|---|---|
| Penn Emotion Identification Task | Baseline (Visit 1) to post-stimulation (Visit 7, within 1 week of last stimulation; Visit 8, within 1 month of last stimulation) | |
| Electroencephalography (EEG) in the alpha (8-12Hz) frequency band | Baseline (Visit 1) to post-stimulation (Visit 7, within 1 week of last stimulation) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kevin Caulfield, PhD | Contact | 843-792-1006 | caulfiel@musc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Kevin Caulfield, PhD | Medical University of South Carolina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MUSC Brain Stimulation Offices | Charleston | South Carolina | 29407 | United States |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| Radiological MRI Safety Scans (T1, T2, diffusion scans, read for abnormalities) | Baseline (Visit 1) to post-stimulation (Visit 7, within 1 week of last stimulation) |