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| ID | Type | Description | Link |
|---|---|---|---|
| R61DC022830-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
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The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
Aim 1 - Visual Exploration in Surgical Patients Investigators will study 20 surgical patients with high-resolution intracranial EEG (iEEG) to investigate hippocampal activity during visual exploration. Participants will view between 10-15 panoramic environments using Meta Quest AR/VR glasses while their eye movements and head turns are tracked. Eye-tracking, head-turn, and iEEG data will be synchronized with visual stimuli, and intracranial EEG and single-unit data will be analyzed for changes in neuronal firing and brain activity before and after saccades.
Aim 2 - Ambulatory Exploration in RNS Patients and Healthy Controls Investigators will study 12 epilepsy patients with implanted responsive neurostimulator (RNS) devices and 24 healthy controls (HCs) during real-world exploration. Participants will walk through and explore visually distinct rooms while wearing synchronized high-density EEG (hdEEG), eye-tracking glasses, and body position sensors. Data from hippocampal iEEG, hdEEG, eye tracking, and motion sensors will be synchronized offline to examine brain-behavior relationships and the influence of cognitive load on saccade-hippocampal interactions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Epilepsy Surgery Patients | Experimental | Aim 1: Participants will be presented with between 10-15 unique immersive virtual environments (depending on patient tolerance) for patients to explore using VR glasses. Control tasks will be run to account for eye movements during non-navigation. For recording eye movements in darkness during REM sleep, as part of a control task, 4 electrodes will be placed above and below both eyes, a standard technique in polysomnographic studies. |
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| Patients with RNS Devices | Experimental | Aim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load). |
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| Healthy Control Participants | Experimental | Aim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Visual Exploration | Other | Cognitive testing while admitted to the epilepsy monitoring unit (number of sessions will vary depending on patient availability and stamina). |
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| Measure | Description | Time Frame |
|---|---|---|
| Hippocampal Theta Power Under High Cognitive Loads | Aims 1 and 2. High cognitive loads defined as visual exploration of a complex scene with goal-driven task. | Study Visit (Day 1) |
| Hippocampal Theta Power Under Medium Cognitive Loads | Aims 1 and 2. Medium cognitive loads defined as visual exploration of a simpler scene with fewer objects. | Study Visit (Day 1) |
| Hippocampal Theta Power Under Low Cognitive Loads | Aims 1 and 2. Low cognitive loads defined as visual exploration of moving dots. | Study Visit (Day 1) |
| Hippocampal Theta Power Under No Cognitive Loads | Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep. | Study Visit (Day 1) |
| Coherence Time-Locked to the Saccade Under High Cognitive Loads | Aims 1 and 2. High cognitive loads defined as visual exploration of a complex scene with goal-driven task. | Study Visit (Day 1) |
| Coherence Time-Locked to the Saccade Under Medium Cognitive Loads | Aims 1 and 2. Medium cognitive loads defined as visual exploration of a simpler scene with fewer objects. | Study Visit (Day 1) |
| Coherence Time-Locked to the Saccade Under Low Cognitive Loads | Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep. |
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Inclusion Criteria:
All subjects:
Aim 1: Surgical epilepsy patients' inclusion criteria
Aim 2: RNS patients Inclusion criteria
Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance
Exclusion Criteria:
RNS patients, Aim 2:
• Any generalized tonic-clonic seizure within the last week
All subjects:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anli Liu, MD, MA | Contact | (929) 455-2323 | Anli.Liu@nyulangone.org | |
| Ayelet Rosenberg | Contact | (646) 558-0893 | Ayelet.rosenberg@nyulangone.org |
| Name | Affiliation | Role |
|---|---|---|
| Anli Liu, MD, MA | NYU Langone Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NYU Langone Health | Recruiting | New York | New York | 10016 | United States |
The study will upload data into openneuro.org or comparable neuroscience data sharing platform, with data uploaded on a basis as specified by the conditions of awards supporting this research.
Beginning 9 months and ending 36 months following article publication or as required by a condition of awards and agreements supporting the research.
Requests should be directed to anli.liu@nyulangone.org. To gain access, data requestors will need to sign a data access agreement. This instance of data sharing will also require separate IRB review as well as review from NYU Langone's DSSB.
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Ambulatory Exploration | Other | Series of cognitive tasks completed during a study visit. |
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| Study Visit (Day 1) |
| Coherence Time-Locked to the Saccade Under No Cognitive Loads | Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep. | Study Visit (Day 1) |