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This pilot study evaluates the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, and young adult Hodgkin lymphoma within 24 months of completing treatment. Preliminary efficacy of the HIIT intervention for improved cardiorespiratory fitness, body composition, physical function, autonomic response to exercise, peripheral neuropathy, biological aging markers, and physical activity will also be evaluated.
Primary Objective:
To determine the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, and young adult Hodgkin lymphoma within 24 months of completing treatment.
Feasibility will be assessed by:
Hodgkin lymphoma survivors face elevated risks of cardiovascular disease and premature aging. HIIT, which alternates high-intensity effort with recovery periods, has shown benefits in adult cancer survivors but has not been tested in younger populations. This study will assess whether recently treated survivors can complete a remotely supervised 12-week HIIT program and evaluate its effects on multiple health outcomes. Participants will undergo baseline and post-intervention assessments including exercise testing, body composition, autonomic function, and blood biomarkers. The intervention is delivered via a secure web-based platform with live supervision by exercise physiologists.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIIT Intervention Group | Experimental | Participants will complete a 12-week HIIT program with three 25-minute sessions per week. Each session includes warm-up, five cycles of high-intensity intervals (80-95% peak HR) and recovery periods (50-60% peak HR), and cool-down. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Intensity Interval Training (HIIT) | Behavioral | Participants will complete a 12-week HIIT program with three 25-minute sessions per week. Each session includes warm-up, five cycles of high-intensity intervals (80-95% peak HR) and recovery periods (50-60% peak HR), and cool-down. |
| Measure | Description | Time Frame |
|---|---|---|
| Participation rate (percent of eligible participants approached who enroll) | Descriptive statistics will be reported | Trial completion (12 weeks) |
| Completion rate (percentage of scheduled HIIT sessions attended and percentage of post-intervention testing sessions completed) | Descriptive statistics will be reported | Trial completion (12 weeks) |
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| Measure | Description | Time Frame |
|---|---|---|
| Cardiorespiratory fitness (VO2peak, ml/kg/min) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Ewing battery score of autonomic function (0 to 5 points) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amy Berkman, MD | Contact | 888-226-4343 | referralinfo@stjude.org |
| Name | Affiliation | Role |
|---|---|---|
| Amy Berkman, MD | St. Jude Children's Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Jude Children's Research Hospital | Recruiting | Memphis | Tennessee | 38105 | United States |
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| Label | URL |
|---|---|
| St. Jude Children's Research Hospital | View source |
| Clinical Trials Open at St. Jude | View source |
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| ID | Term |
|---|---|
| D006689 | Hodgkin Disease |
| ID | Term |
|---|---|
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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|
Descriptive statistics of the change between baseline and 12 weeks will be reported
| baseline at study entry, 12 weeks |
| Body mass index (weight and height will be combined to report body mass index in kg/m2) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Percent body fat (%) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Lean mass percentage (%) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Visceral fat level (score) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Hand grip strength (kg) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Knee extension strength (N/kg) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Modified total neuropathy scale (0 to 24 points) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| DNA methylation | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Mitochondrial DNA copy number | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Telomere length (kb) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| High-sensitivity C-reactive protein (mg/L) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Interleukin-6 (pg/mL) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| Physical activity (kilocalories per week) | Descriptive statistics of the change between baseline and 12 weeks will be reported | baseline at study entry, 12 weeks |
| D008206 |
| Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |