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The goal of this clinical trial is to determine if utilizing the Quest AD-Detect blood test, while patient's are hospitalized for a cognitive diagnosis (such as delirium or encephalopathy), will result in an earlier diagnosis of underlying Alzheimer's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All eligible patients will receive a Quest AD-Detect blood test | Other | All patients that meet the inclusion criteria, and none of the exclusion criteria, will have their blood tested with the Quest AD-Detect |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quest AD-Detect blood test | Diagnostic Test | Blood will be collected and sent for testing using the Quest AD-Detect blood test |
|
| Measure | Description | Time Frame |
|---|---|---|
| To show the percentage of patients (21 patients in the study) who presented with a cognitive diagnosis (including but not limited to delirium, encephalopathy, etc.) that have a positive biomarker for Alzheimer's dementia | A Six month follow up with the Neurology clinic to discuss the results of Quest AD Detect (p-tau217), those patients who are found to have a positive outcome will receive additional follow-up in the Neurology clinic (which could include the use of additional lab tests or further diagnostic testing). | From enrollment to 6 month follow up appointment with Neurology Clinic. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Clinical Research Nurse Coordinator | Contact | 865-331-1337 | aholt10@covhlth.com |
| Name | Affiliation | Role |
|---|---|---|
| Samuel Moore, MD | Covenant Health, Canada | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cumberland Medical Center | Recruiting | Crossville | Tennessee | 38555 | United States |
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| Roane Medical Center | Recruiting | Harriman | Tennessee | 37748 | United States |
|
| Fort Sanders Regional Medical Center | Recruiting | Knoxville | Tennessee | 37916 | United States |
|
| Fort Loudon Medical Center | Recruiting | Lenoir City | Tennessee | 37772 | United States |
|
| Methodist Medical Center | Recruiting | Oak Ridge | Tennessee | 37830 | United States |
|
| LeConte Medical Center | Recruiting | Sevierville | Tennessee | 37862 | United States |
|
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D003221 | Confusion |
| D001927 | Brain Diseases |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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