Oral Methadone in Cardiac Surgery

Oral Methadone In Cardiac Surgery

The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.

Inclusion Criteria:

• Undergoing elective cardiac surgery

Exclusion Criteria:

• Chronic pain requiring opioid medications as an outpatient
• Opioid use disorder on medication assistance treatment
• Prolonged QTc >500ms
• Chronic kidney disease with eGFR < 30mL/min
• Documented cirrhosis
• Intolerance to methadone
• Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery
• Pregnancy at the time of surgery
• Subsequent surgeries after index surgery