Oral Methadone in Cardiac Surgery | NCT07221617 | Trialant

Oral Methadone in Cardiac Surgery | NCT07221617 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Intravenous methadone intraoperatively	Active Comparator	Subjects in the IV methadone arm will receive methadone intravenously during cardiac surgery	Drug: Methadone, intravenously
Oral methadone, immediately prior to transport	Experimental	Subjects in the oral methadone arm will receive methadone orally prior to cardiac surgery	Drug: Methadone, oral

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Methadone, oral	Drug	Patients will receive 0.4mg/kg PO methadone immediately prior to transport to the operating room	Oral methadone, immediately prior to transport

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Amount of opioid medication used 72 hours post-extubation	Opioid medication used at 72 hours post-extubation will be reported in morphine milligram equivalents	From hospital admission for surgery to 72 hours after the patient is extubated postoperatively

Secondary Outcomes

Measure	Description	Time Frame
Amount of opioid medication used 24 hours post-extubation	Opioid medication used at 24 hours post-extubation will be reported in morphine milligram equivalents	From hospital admission for surgery to 24 hours after the patient is extubated postoperatively
Amount of opioid medication used 48 hours post-extubation

Contacts/Locations Module

Condition Browse Module