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A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery
The MOVE Protocol is a structured, biomechanics-based rehabilitation framework designed to accelerate recovery from musculoskeletal pain conditions through progressive mobilization and neuromuscular control. This interventional case-series involved multiple clinical and training centers (BodyGNTX, GFFI, IIKBS, ASFU) and applied standardized MOVE sessions under the supervision of certified movement specialists. Assessments included pain scoring (NRS), functional mobility (LEFS/UEFI), and balance control, measured at baseline, week 2, week 4, and week 8. The protocol followed ICH-GCP E6(R2) and Helsinki 2013 guidelines, with institutional ethics approval from MMSx Authority IREB. The study demonstrated safe and effective early-movement outcomes across diverse populations, emphasizing mobility, load optimization, and neuromuscular revalidation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Move Protocol | Experimental | Participants received the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation protocol, consisting of four progressive phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery. The program emphasized functional movement restoration, load tolerance, and neuromuscular coordination. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MOVE Rehabilitation Protocol | Behavioral | The MOVE (Movement-Oriented Velocity of Engagement) protocol is a biomechanics-based rehabilitation approach targeting early mobilization and functional recovery for musculoskeletal pain conditions. The structured program includes four key phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery, applied over 8 weeks under therapist supervision. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Reduction (NRS Score) | Change in Numeric Rating Scale (NRS) for pain intensity from baseline to week 8 following the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation program. Participants rated pain on a 0-10 scale where 0 = no pain and 10 = worst possible pain. | Baseline, Week 2, Week 4, and Week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Functional Improvement (LEFS / UEFI Score) | Change in Lower Extremity Functional Scale (LEFS) or Upper Extremity Functional Index (UEFI) from baseline to week 8, reflecting mobility and activity performance improvement post-MOVE intervention. | Baseline, Week 2, Week 4, Week 8 |
| Balance and Postural Stability (Timed Single-Leg Stance Test) |
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Inclusion Criteria:
• Adults aged 18-65 years diagnosed with acute or subacute musculoskeletal pain or movement restriction (≤12 weeks duration).
Exclusion Criteria:
Chronic pain (>12 weeks) or neurological disorders affecting movement control.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BodyGNTX Fitness Institute | Columbus | Ohio | 43220 | United States | ||
| MMSx AUTHORITY (COORDINATING CENTER) |
De-identified participant data are stored securely at MMSx Authority Clinical Research Division and affiliated academic centers (BodyGNTX USA, GFFI India, IIKBS). Data will not be shared publicly but may be used in aggregate form for institutional publications.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jun 15, 2024 | Oct 22, 2025 | Prot_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 15, 2024 | Oct 22, 2025 | ICF_001.pdf |
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This was a multi-site, single-arm interventional case-series evaluating the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation protocol for acute and subacute musculoskeletal pain. Forty participants across four international centers completed an 8-week standardized intervention consisting of four progressive phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery. The study aimed to assess safety, functional recovery, and pain reduction outcomes following the MOVE protocol.
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Open-label rehabilitation study. Both investigators and participants were aware of the intervention procedures, as exercise-based protocols require therapist supervision and participant engagement.
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Improvement in single-leg stance duration and balance control across sessions as measured by standardized postural tests. |
| Baseline, Week 4, Week 8 |
| Participant Perceived Recovery (Global Rating of Change Scale) | Participants rate overall improvement on a 7-point Global Rating of Change (GROC) scale at week 8 to capture subjective recovery perception. | Week 8 |
| Powell |
| Ohio |
| 43065 |
| United States |
| Indian Institute of Kinesiology & Biomechanics Science (IIKBS) | Burhānpur | Madhya Pradesh | 450331 | India |
| GFFI Fitness Academy | New Delhi | National Capital Territory of Delhi | 110026 | India |