Zynrelef Versus Adductor Canal Block

Comparing Opioid Consumption Following Total Knee Arthroplasty With The Perioperative Administration of Zynrelef Versus Adductor Canal Block

To compare postoperative MME consumption 72 hours after TKA in patients receiving intraoperative periarticular HTX-011 (Zynrelef) instillation versus adductor canal block.

Inclusion Criteria:

• Patients > 18 years of age
• Patients undergoing primary, unilateral total knee arthroplasty
• Ability to provide informed consent

Exclusion Criteria:

• Individuals under the age of 18
• Pregnant women
• Prisoners
• Adults unable to consent
• American Society of Anesthesiologists Physical Status score greater than 3
• Patients taking any of the following medications before surgery:
• Long-acting opioids within 3 days
• Any opioids taken within 24 hours
• Bupivacaine HCL within 5 days
• Chronic opioid use or patients with known or suspected daily use of opioids for seven or more consecutive days within 6 months before their scheduled surgery
• Illicit drug use determined by social history
• Alcohol abuse determined by a CAGE Substance Abuse Screening Tool Score of at least two or greater
• Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF
• Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients