Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| The Scientific and Technological Research Council of Turkey | OTHER |
Not provided
Not provided
Not provided
This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stage III Grade C :Non surgical periodontal therapy and an adjunct diode laser use | Experimental |
| |
| Stage III Grade C :Non surgical periodontal therapy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diode Laser Application in Deep Periodontal Pockets | Device | A 940 nm indium-gallium-aluminum-phosphate diode laser (Ezlase, Biolase, USA) with a 400 μm fiber was used in contact mode at 1.5 W, pulse 20/20 ms, 20 s/cm², power density 1.061 W/cm², and 15 J/cm² energy in deep periodontal pockets. |
| Measure | Description | Time Frame |
|---|---|---|
| Probing Pocket Dept (PPD) | The probing pocket dept was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth. | Through study completion, an average of 3 months. |
| Periodontal Epithelial Surface Area (PESA) | PESA represents the total epithelial surface area in periodontal pockets. | Through study completion, an average of 3 months. |
| Periodontal Inflamed Surface Area (PISA) | PISA quantifies the inflamed portion of this surface area by integrating only sites exhibiting BOP, both measured in mm2. | Through study completion, an average of 3 months. |
| Salivary Malondialdehyde Levels | Evaluation of salivary malondialdehyde levels. | Through study completion, an average of 3 months. |
| Salivary 8-hydroxy-2'-deoxyguanosine Levels | Evaluation of salivary 8-hydroxy-2'-deoxyguanosine levels. | Through study completion, an average of 3 months. |
| PPD ≥4 mm, site-specific PPD (ssPPD) | For sites with PPD ≥4 mm, site-specific PPD (ssPPD) values was calculated. | Through study completion, an average of 3 months. |
| PPD ≥4 mm, site spesific CAL (ssCAL) | For sites with PPD ≥4 mm, site spesific CAL (ssCAL) values were also calculated. |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque Index (PI) | The plaque index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth. | Through study completion, an average of 3 months. |
| Bleeding on Probing (BOP) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Selcuk University Faculty of Dentistry Department of Periodontology | Konya | Selçuklu | 42250 | Turkey (Türkiye) |
Not provided
Not provided
Not provided
Not provided
To ensure allocation concealment and maintain the masked design, the following protocol was applied: After diagnosis at the Department of Oral Diagnosis and Radiology, baseline periodontal records and anamnesis were documented, and each patient was assigned a unique ID. Eligible participants underwent baseline clinical measurements (D.İ.A) and saliva sampling. Patients were then randomly allocated to SRP (n=17) or SRP+DL (n=16) using a computer-generated program (Sealed Envelope Ltd.) by an independent clinician not involved in the study. One week later, SRP and diode laser procedures were performed by the same clinician (D.İ.A). For blinding, all clinical files were anonymized and coded by the study supervisor (S.S.H). Statistical analyses were conducted by a blinded statistician without access to group assignments.
|
| Professional Mechanical Plaque Removal | Procedure | Professional mechanical removal of supragingival plaque and calculus |
|
| Scaling and Root Planing | Procedure | Subgingival scaling and root planing |
|
| Through study completion, an average of 3 months. |
| PPD ≥4 mm, site-specific PISA (ssPISA) | For sites with PPD ≥4 mm, site-specific PISA (ssPISA) values were calculated. | Through study completion, an average of 3 months. |
| PPD ≥4 mm, site-specific PESA (ssPESA) | For sites with PPD ≥4 mm, site-specific PESA (ssPESA) values were calculated. | Through study completion, an average of 3 months. |
The bleeding on probing index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth. |
| Through study completion, an average of 3 months. |
| Clinical Attachment Level (CAL) | The clinical attachment level was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth. | Through study completion, an average of 3 months. |
| Gingival Index (GI) | The gingival index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth. | Through study completion, an average of 3 months. |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D012907 | Smoking |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D001519 | Behavior |
Not provided
Not provided
| ID | Term |
|---|---|
| D014080 | Tooth Exfoliation |
| D016745 | Root Planing |
| ID | Term |
|---|---|
| D009063 | Dental Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
| D012534 | Dental Scaling |
| D003777 | Dental Prophylaxis |
| D010517 | Periodontics |
| D003813 | Dentistry |
| D013357 | Subgingival Curettage |
| D011313 | Preventive Dentistry |
Not provided
Not provided