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The aim of the observational study is to compare safety, clinical efficacy and time-to-event survival in patients age of 60-74 years with degenerative aortic valve disease that underwent aortic valve replacement with either stented biological prosthesis or aortic allograft.
Early safety included morbidity, mortality rate, freedom from any valve related complications Clinical efficacy included mid-term survival, freedom from reoperation, repeat endocarditis and other valve related complication Time-to-event analysis included freedom from all-cause and cardio-vascular mortality, freedom from stroke, major bleeding, endocarditis, structural valve deterioration and reoperation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stented biological prosthesis | Patients who underwent aortic valve replacement with stented biological valve |
| |
| Allograft aortic root replacement | Patients who underwent allograft aortic root replacement |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aortic valve/root replacement | Procedure | Aortic valve or aortic root replacement with stented biological prosthesis or aortic allograft |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Early cardio-vascular mortality | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Cardio-vascular mortality | 2 years |
| Mortality | All-cause mortality | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with degenerative aortic valve disease, age 60-74 years
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| Structural valve deterioration | New onset aortic regurgitation (vc >0,6) or escalated mean pressure gradient over 20 mmHg. | 2 years |
| Stroke | Ischemic stroke | 2 years |
| Reoperation | Reoperation for valve failure | 2 years |
| Endocarditis | Prosthetic valve endocarditis | 2 years |