Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| The Craig H. Neilsen Foundation | OTHER |
Not provided
Not provided
Not provided
Not provided
The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic Spinal Cord Injury | Experimental |
| |
| Acute Spinal Cord Injury | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tests of sympathetic inhibition | Diagnostic Test | Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses. |
| Measure | Description | Time Frame |
|---|---|---|
| Valsalva Maneuver Phase II | Presence or absence of phase II on Valsalva maneuver testing, which takes approximately 15 seconds to complete. This will be repeated x3. | During laboratory diagnostic testing session |
| Measure | Description | Time Frame |
|---|---|---|
| Beat-to-beat heart rate | Electrocardiogram will record continuous measures with changes in R-R interval (ms) quantified and compared to baseline. | During laboratory diagnostic testing session |
| Beat-to-beat blood pressure |
Not provided
Inclusion criteria
Exclusion criteria
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erin Lund | Contact | 507-284-9298 | lund.erin@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Ryan J. Solinsky, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Recruiting | Rochester | Minnesota | 55905 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38854077 | Background | Solinsky R, Burns K, Hamner JW, Singer W, Taylor JA. Characterizing preserved autonomic regulation following spinal cord injury: Methods of a novel concerted testing battery and illustrative examples of a new translationally focused data representation. medRxiv [Preprint]. 2024 Jun 1:2024.05.31.24308290. doi: 10.1101/2024.05.31.24308290. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Tests of above level sympathetic activation | Diagnostic Test | Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II). |
|
| Testing of below level sympathetic activation | Diagnostic Test | Cold pressor test of the foot and bladder pressor response will be tested. |
|
Non-invasive continuous blood pressure monitors will be used, with changes in systolic and diastolic pressure (in mmHg) from resting baseline measured.
| During laboratory diagnostic testing session |
| Continuous galvanic skin response | Changes from resting state conductance with be quantified with a smartwatch. | During laboratory diagnostic testing session |
| Quantify autonomic dysreflexia and orthostatic hypotension | Participants will be given the Autonomic Dysfunction Following Spinal Cord Injury questionnaire (score range 0-436, with higher scores indicating more autonomic dysfunction). | Baseline, prior to laboratory diagnostic testing session |
| Respiration | Elastic respiratory transducer bands around mid-chest and upper abdomen will monitor breathing depth and frequency. | During laboratory diagnostic testing session |
| Beat-by-Beat Popliteal and Brachial Blood Flow | The investigators will use Doppler derived flow velocities to estimate whole limb blood flow through the popliteal and brachial arteries | During laboratory diagnostic testing session |
| Immunology Blood Draw | Baseline samples will be collected and compared against changes to blood pressure. | During laboratory diagnostic testing session |
| Serum Catecholamines and Cortisol | Baseline resting catecholamines (norepinephrine, epinephrine, dopamine) and cortisol will be drawn from the IV after 10 minutes of quiet rest at baseline and prior to bladder filling or foot cold pressor. Just prior to the conclusion of this testing, an additional blood draw will take place through the IV to assess changes in these levels. | During laboratory diagnostic testing session |
| Pressure-induced vasodilation | Changes to skin blood flow following a gradual change in pressure to the skin surface area. Laser doppler will be used to monitor changes in blood flow. | During laboratory diagnostic testing session |
| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
Not provided
Not provided