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We investigated whether video-based education using deepfake technology could improve blood pressure measurement adherence and medication adherence in patients with ischemic heart disease accompanied by hypertension.
Hypertension is a major risk factor for recurrent cardiovascular events in patients with ischemic heart disease, yet adherence to home blood pressure monitoring and prescribed medications remains suboptimal. Personalized and engaging educational strategies may help to improve adherence behaviors in this population.
This randomized controlled trial investigates the effectiveness of a video-based educational program, developed with deepfake technology, to deliver individualized health information. Participants are randomly assigned to either the intervention group, which receives the video education in addition to usual care, or the control group, which receives usual care alone.
The primary outcomes are adherence to home blood pressure monitoring and medication adherence after one month. Secondary outcomes include changes in office and home blood pressure, as well as 24-hour ambulatory blood pressure monitoring. The results of this study may provide evidence for scalable, technology-assisted strategies to enhance adherence and improve blood pressure control in high-risk cardiovascular patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Video education | Experimental | Participants receive personalized video-based education developed using deepfake technology to replicate the patient's primary physician's voice, in addition to usual care. |
|
| Standard Care | Active Comparator | Participants receive standard treatment for ischemic heart disease and hypertension, without additional video-based education. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Video Education | Behavioral | Videos were created using deepfake technology, utilizing AI to replicate the voice of the patients' primary physician. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adherence to Home Blood Pressure Monitoring (HBPM) | Proportion of days during the 30-day follow-up period in which participants recorded four BP measurements per day (two in the morning, two in the evening) using a validated home BP device (InBody BP170). | 4 weeks |
| Medication Adherence Assessed by Pill Count | Proportion of prescribed antihypertensive medication doses taken during the 30-day follow-up period, assessed by pill counts at the follow-up visit. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Office Systolic Blood Pressure From Baseline to 4 Weeks | Mean change in systolic blood pressure (SBP) measured in clinic using a standardized sphygmomanometer at baseline and 4 weeks. | 4 weeks |
| Change in Office Diastolic Blood Pressure From Baseline to 4 Weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Keimyung University Dongsan Hospital | Daegu | Daegu | 42601 | South Korea |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D017202 | Myocardial Ischemia |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
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| Control | Other | Standard treatment |
|
Mean change in diastolic blood pressure (DBP) measured in clinic using a standardized sphygmomanometer at baseline and 4 weeks. |
| 4 weeks |
| Difference in Mean Systolic Blood Pressure Between Home BP Monitoring and 24-Hour Ambulatory Monitoring | Difference between mean SBP values obtained from home BP monitoring (HBPM) and 24-hour ambulatory BP monitoring (ABPM). | 4 weeks |
| Difference in Mean Diastolic Blood Pressure Between Home BP Monitoring and 24-Hour Ambulatory Monitoring | Difference between mean DBP values obtained from HBPM and ABPM. | 4 weeks |
| Number of Antihypertensive Medications Prescribed Per Participant | Total number of prescribed antihypertensive medications per participant at baseline and at 4 weeks. | 4 weeks |
| Distribution of Antihypertensive Medication Classes Used | Proportion of participants prescribed each class of antihypertensive medication (RAAS inhibitors, beta-blockers, calcium channel blockers, diuretics, etc.) at baseline and 4 weeks. | 4 weeks |