This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.

Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients.

Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied.

The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.

Inclusion Criteria:

• Age from 18 to 70 years old.
• Both sexes.
• Septic patients (under the third international consensus definitions of sepsis and septic shock).

Exclusion Criteria:

• Pregnancy
• Malignancy
• On immunosuppressive therapy
• Hematological Disorders
• Major Trauma
• Major Burns
• Child-Pugh Class C Liver Cirrhosis
• On Hemodialysis

A prospective observational study will be conducted at Ain Shams University Hospital, Cairo, Egypt.

The data will be available upon a reasonable request from the corresponding author after the end of study for one year.

After the end of study for one year.

The data will be available upon a reasonable request from the corresponding author.