Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival

Association Between Elevated Plasma D-dimer in Adult Community-acquired Pneumonia Patients and Severity of Inflammatory Response and Survival

This observational study aims to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as its impact on survival in adult patients with community-acquired pneumonia.

the study participants will be subjected to sampling for D-dimer and calculation of CURB-65 score. this aims to find the relation between them

Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection that affects millions of individuals worldwide each year.

D-dimer is a fibrin degradation product that is elevated in many conditions associated with inflammation and coagulation activation, including pneumonia.

This is an observational study including a minimum of 50 patients with CAP

Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:

1. age ≥18 years
2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.
3. Did not have any clinical or radiological signs suggesting COVID-19 pneumonia Exclusion criteria Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.

All patients will be subjected to the following: -

1. Full medical history, demographics
2. Thorough clinical examination.
3. laboratory values (including white blood cell count, CRP, and D-dimer), With pre and post sample known precautions (8).
4. Radiological findings (CXR).
5. Severity of illness (based on the CURB-65 score).

Inclusion Criteria:

• Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:

  1. age ≥18 years
  2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.

Exclusion Criteria:

• Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
• patients who have any clinical or radiological signs suggesting COVID-19 pneumonia.