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The goal of this study is to compare the proportion of compensatory hyperhidrosis patients after sympathectomy at T3 level and sympathectomy at T3-4 level. The main question it aims to answer is:
can sympathectomyv at one level decrease the incidence of compensatory hyperhidrosis after primary hyperhidrosis.
Primary hyperhidrosis is a chronic condition characterized by excessive sweating beyond physiological needs, commonly affecting the palms, axillae, face, or soles. This disorder is largely attributed to neurogenic hyperexcitability within the sympathetic nervous system's pathways innervating the eccrine sweat glands.When conservative treatments such as topical agents or oral medications fail, endoscopic thoracic sympathectomy (ETS) is considered an effective surgical option. However, a major postoperative complication is compensatory hyperhidrosis (CH)-the development of excessive sweating in previously unaffected areas such as the trunk, back, or thighs. CH can significantly impact patient satisfaction and quality of life, often becoming more distressing than the original condition.
The extent and level of sympathectomy have been proposed as key factors influencing the incidence and severity of CH. While higher levels or multilevel resections (e.g., T2-4) are associated with increased rates of CH, more limited approaches such as T3-only resection are thought to reduce this risk. However, definitive evidence comparing T3 versus T3-4 sympathectomy remains limited and inconsistent across studies.
This study aims to compare the incidence and severity of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy for primary hyperhidrosis. Understanding these differences may help refine surgical approaches to minimize CH and improve patient outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| T3 sympathectomy | patients who underwent T3 sympathectomy for primary hyperhidrosis | ||
| T3-4 sympathectomy | patients who underwent through T3-4 sympathectomy for primary hyperhidrosis |
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| Measure | Description | Time Frame |
|---|---|---|
| To compare the incidence of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy. | 1 year post-sympathectomy |
| Measure | Description | Time Frame |
|---|---|---|
| severity of Compensatory hyperhidrosis by hyperhidrosis disease severity scale |
| 1 year post sympathectomy |
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Inclusion Criteria:
Exclusion Criteria:
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population of study are patients with primary hyperhidrosis who are going through T3 or T3-4 sympathectomy.
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19897823 | Background | Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009 Nov;41(4):1149-60. doi: 10.3758/BRM.41.4.1149. | |
| 15280843 | Background | Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004 Aug;51(2):241-8. doi: 10.1016/j.jaad.2003.12.040. |
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| ID | Term |
|---|---|
| D006945 | Hyperhidrosis |
| ID | Term |
|---|---|
| D013543 | Sweat Gland Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| recurrence rates of primary hyperhidrosis | 1 year post sympathectomy |
| site of compensatory hyperhidrosis | 1year post sympathectomy |
| Background | 4. Lin TS, et al. Clinical experience of thoracoscopic sympathetic block for primary hyperhidrosis: analysis of 3450 cases. J Thorac Cardiovasc Surg. 2001;121(3):566-74. |
| Background | 3. Hussein AF, et al. Unilevel (T3) versus Bilevel (T3 - T4) Sympathictomy in the Management of Palmar Hyperhidrosis: A Prospective Comparative Study. Clinics (Sao Paulo). 2024. |
| Background | 2. Liu X, Wang J, Liu Z, Sun X, Zheng J. Comparison of only T3 and T3-T4 sympathectomy for axillary hyperhidrosis: a retrospective study. J Thorac Dis. 2018;10(4):2095-101. |
| 17695343 | Background | Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146. |
| 15276490 | Background | Licht PB, Pilegaard HK. Severity of compensatory sweating after thoracoscopic sympathectomy. Ann Thorac Surg. 2004 Aug;78(2):427-31. doi: 10.1016/j.athoracsur.2004.02.087. |