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This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.
Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined.
In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors.
By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.
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| Measure | Description | Time Frame |
|---|---|---|
| RIFLE criteria classification at CRRT initiation | Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed. | Baseline( Day0, at CRRT initiation) |
| Timing of CRRT initiation | Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records. | Baseline( Day0, at CRRT initiation, recorded from patient medical records) |
| Survival status of patients | Survival versus non-survival status at the end of hospitalization. | At hospital discharge ( end of hospitalization) |
| Measure | Description | Time Frame |
|---|---|---|
| Presence of comorbidities in non-survivors | Documentation of chronic comorbidities (e.g., diabetes, hypertension, cardiovascular disease) in patients who died after CRRT. | Baseline( Day0, at hospital admission) |
| Requirement for mechanical ventilation in non-survivors |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients (≥18 years) admitted to and treated in the Burn Intensive Care Unit.
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| Name | Affiliation | Role |
|---|---|---|
| Elif Bombaci, MD | Dr.Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation, İstanbul, Turkey | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Lutfi Kirdar City Hospital, Department of Anesthesiology and Reanimation | Istanbul | 34865 | Turkey (Türkiye) |
Individual participant data (IPD) will not be shared due to patient confidentiality and ethical considerations.
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| ID | Term |
|---|---|
| D002056 | Burns |
| D058186 | Acute Kidney Injury |
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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Need for invasive mechanical ventilation among non-survivors receiving CRRT. |
| Through ICU stay, up to hospital discharge (or death) |
| Requirement for inotropic support in non-survivors | Requirement for vasopressor or inotropic agents among non-survivors receiving CRRT. | Through ICU stay, up to hospital discharge or death |
| Hospital length of stay in non-survivors | Total length of hospitalization measured in days for patients who did not survive after CRRT. | From hospital admission through study completion( up to discharge or death) |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |