The goal of this observational study is to explore the association between multiple sclerosis and periodontal disease in a sample of Egyptian population

The main question it aims to answer is:

• Is there an association between MS and periodontal disease Participants already diagnosed with multiple sclerosis. A conventional oral examination will be held on a dental unit, filling charts and patients' acceptance to participate in the survey.

Periodontal disease is a chronic inflammatory condition leading to progressive destruction of the supporting structures of the teeth. Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that may share common inflammatory pathways with periodontal disease. Recent evidence suggests that systemic inflammation may influence the severity and progression of both conditions.

This study will recruit participants already diagnosed with MS and assess their periodontal status using standard clinical parameters, including clinical attachment loss (CAL), probing pocket depth, and bleeding on probing measured at six sites per tooth using a periodontal probe. Data will be collected through a conventional oral examination in a dental unit, and results will be compared to evaluate the prevalence and potential association between MS and periodontal disease within this population.

Inclusion Criteria:

• Patients diagnosed with MS
• Adult patients ≥ 18 years old.
• Patients providing an informed consent

Exclusion Criteria:

• Periodontal therapy within the last 3 months.
• Having surgical therapy or undergoing orthodontic treatment
• Smokers
• Pregnant females
• Patients with systemic condition know to impact the periodontal condition other than MS (eg. Diabetes Mellitus)
• Patients having more than 5 lost teeth

MS patients to be recruited and selected from sheikh Zayed Al-Nahayan Hospital

Individual participant data will not be shared due to privacy considerations and limitations in data-sharing infrastructure. Only aggregate study results will be published and made publicly available.