Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire

Lynch Syndrome Carriers' Uterine Cancer Health Assessment: Sampling and DNA-based Detection

The goal of this study is to find out if self-collected vaginal swabs can be used to detect early signs of uterine cancer or related conditions in people with Lynch syndrome (LS) who still have their uterus. The study also tests if people with LS are willing and able to collect these samples themselves and whether they find the process acceptable.

The main questions this study asks are:

• Will people with LS take part in self-collection of vaginal samples, and do they find it acceptable?
• Can vaginal DNA mutations predict cancer risk or match results from other genetic or biopsy testing?
• Can a cancer risk model used in the general population also help identify risk in people with LS?

Participants will:

• Answer a health questionnaire about lifestyle and symptoms
• Collect their own vaginal swabs and measure their vaginal pH at home using a self-collection kit
• Complete short surveys around the time of self-collection and at the end of the study

Inclusion Criteria:

• Diagnosed with Lynch syndrome (confirmed by genetic testing).
• Have an intact uterus.
• Age 30 years or older.

Exclusion Criteria:

• History of endometrial cancer or endometrial hyperplasia.
• History of pelvic radiation or endometrial ablation.
• Pregnant at the time of study enrolment or during the study.