Dose-Efficacy of rTMS in Healthy Young Female Volunteers

Randomized Cross-Over Dose-Efficacy Study of rTMS in Healthy Young Female Volunteers

This study is aimed to develop a new therapy based on non-invasive repetitive magnetic stimulation rehabilitation for FI in patients who do not respond to conventional therapies.

AIMS 1) General: to develop a new therapy based on non-invasive repetitive magnetic stimulation rehabilitation for FI in patients who do not respond to conventional therapies. 2) Specific: a) To evaluate the optimal dose of cortical magnetic stimulation (rTMS) and lumbosacral magnetic stimulation (rTLS) in young healthy women for its subsequent application in patients with FI. b) To assess the effect of rTMS and rTLS on continence, clinical severity, and QoL in women with FI.

DESIGN: 1. Cross-over clinical trial dose-efficacy study: Evaluation of the dose-efficacy of acute rTMS and rTLS in 30 healthy young women. Frequencies will be evaluated for cortical rTMS (1Hz and 5Hz) and 3 rTLS (1, 5, and 10Hz).

Inclusion Criteria:

• no history of FI
• Be a woman
• capable of understanding and providing informed consent

Exclusion Criteria:

• pregnancy and the ability to become pregnant
• presence of a pacemaker
• history of epilepsy or neurosurgery
• poor treatment tolerance