A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084 in Combination With Subcutaneous Pembrolizumab and Berahyaluronidase Alfa (MK-3475A) Versus MK-3475A in Combination With Pemetrexed/Platinum (Carboplatin or Cisplatin) Chemotherapy as First-line Treatment of Participants With KRAS G12C-Mutant, Advanced or Metastatic Nonsquamous NSCLC (KANDLELIT-007)
A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084 in Combination With Subcutaneous Pembrolizumab and Berahyaluronidase Alfa (MK-3475A) Versus MK-3475A in Combination With Pemetrexed/Platinum (Carboplatin or Cisplatin) Chemotherapy as First-line Treatment of Participants With KRAS G12C-Mutant, Advanced or Metastatic Nonsquamous NSCLC (KANDLELIT-007)
Researchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation.
The goal of this study is to learn if people who receive calderasib with SC pembrolizumab live longer without the cancer growing or spreading than in people who receive SC pembrolizumab with chemotherapy.
Inclusion Criteria:
The main inclusion criteria include but are not limited to the following:
Exclusion Criteria:
The main exclusion criteria include but are not limited to the following:
Trialsites@msd.com1-888-577-8839
Birmingham, Alabama 35209, United States
205-949-1907
Farmington, Connecticut 06030-8010, United States
Lafayette, Indiana 47904, United States
Hackensack, New Jersey 07601, United States
Lancaster, Pennsylvania 17601, United States
Fredericksburg, Virginia 22408, United States
Ciudad Autónoma de Buenos Aires, Buenos Aires C1426ANZ, Argentina
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Mar del Plata, Buenos Aires B7600FZO, Argentina
Frankston, Victoria 3199, Australia
Graz, Styria 8036, Austria
Vienna, 1210, Austria
Fortaleza, Ceará 60336-232, Brazil
Porto Alegre, Rio Grande do Sul 90110-270, Brazil
Florianópolis, Santa Catarina 88020-210, Brazil
Ribeirão Preto, São Paulo 14048-900, Brazil
Santiago, Region M. de Santiago 7500653, Chile
Beijing, Beijing Municipality 100142, China
Beijing, Beijing Municipality 100730, China
Fujian, Fujian 350005, China
0591 8798 3333
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Guangzhou, Guangdong 510080, China
Guangzhou, Guangdong 510095, China
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Jiamusi, Heilongjiang 154007, China
Wuhan, Hubei 430030, China
Nanjing, Jiangsu 210000, China
Xi'an, Shaanxi 710061, China
Shanghai, Shanghai Municipality 200433, China
Chongqing, Sichuan 400030, China
023-65301682
Hangzhou, Zhejiang 310003, China
Taizhou, Zhejiang 317000, China
Bogotá, Bogota D.C. 111321, Colombia
Vandœuvre-lès-Nancy, Meurthe-et-Moselle 54500, France
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+97289542196
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Verona, 37126, Italy
Himeji, Hyōgo 670-8520, Japan
Sakai, Osaka 591-8555, Japan
Takatsuki, Osaka 569-8686, Japan
Ureshino, Saga-ken 843-0393, Japan
Bunkyo, Tokyo 113-8603, Japan
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Bunkyo, Tokyo 113-8677, Japan
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