The study is being conducted to evaluate the safety and pharmacokinetic characteristics of SHR8554 injection in subjects with renal insufficiency and healthy subjects.

Inclusion Criteria:

1. Able and willing to provide a written informed consent;
2. The estimated glomerular filtration rate (eGFR) of subjects in groups must meet the corresponding standards;
3. Male or female;
4. with a body mass index (BMI) between 18.0 and 28.0 kg/m2.

Exclusion Criteria:

1. History of clinically significant allergies, known allergy to SHR8554, or any other structural analogs;
2. Subjects with positive tests for infectious diseases;
3. Pregnancy or lactation women, or a fertility male or female is not willing to contraception during test;
4. Unable to tolerate venipunctures or have a history of fainting needles and blood;
5. Historic abuse of alcoholic beverages;
6. Smoke ≥ 10 cigarettes per day within 3 months prior to the study;
7. History of drug abuse;
8. Diseases with abnormal clinical manifestations that occurred before screening or are currently occurring and need to be excluded for normal renal function group;
9. Vital signs, physical examination, 12-lead electrocardiogram, or laboratory examination deemed clinically significant by the investigator for normal renal function group;
10. History of renal transplantation and/or requirement for renal dialysis treatment during the study period for severe renal function group;
11. Urinary incontinence or anuria (e.g., < 100 mL/day) for severe renal function group;
12. Other reasons that the investigator consider it inappropriate to participate in the trial.