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The main purpose of the study is to characterize the production of hepatokines (FGF21 and Follistatin) in response to a submaximal exercise on an ergocycle, in patients with hepatocellular carcinoma. The effect of exercise on hepatokines and metabolites production in liver cancer patients is not known. Studying this production could help to provide relevant recommendations for training programming in these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single arm | Experimental | A single study visit will be required, during which the following will be caried out:
Snacks will be served afterwards. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | 30-minutes exercise on a bicycle with heart rate monitor and gas exchange analyzer. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Systemic hepatokines rates (FGF-21 and follistatin) | Blood samples | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle pain assessment | Visual analog scale. Score from 0 (total absence of muscle pain) to 10 (maximum muscle pain). | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Fatigue assessment | Visual analog scale. Score from 0 (total absence of fatigue) to 10 (maximum fatigue). | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise |
| Perception of effort assessment |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lise Laclautre | Contact | 0473754963 | promo_interne_drci@chu-clermontferrand.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Estaing Medecine Digestive Et Hepatobiliaire | Clermont-Ferrand | 63003 | France |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Borg scale
| Baseline (at the beginning), periprocedural (middle of exercise), immediately after exercise |
| Production of metabolites | Blood samples | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise |
| CHU de Clermont-Ferrand | Clermont-Ferrand | France |
|