A Prospective Observational Study on Pulmonary Hypertension in Patients With Obstructive Sleep Apnea: Correlation of Apnea-Hypopnea Severity With Pulmonary Artery Pressures
A Prospective Observational Study on Pulmonary Hypertension in Patients With Obstructive Sleep Apnea: Correlation of Apnea-Hypopnea Severity With Pulmonary Artery Pressures
This study investigates the association between obstructive sleep apnea (OSA) and pulmonary hypertension (PH), focusing on the relationship between OSA severity and pulmonary arterial pressures in adult patients.
This prospective, observational, cross-sectional study will be conducted in the pulmonology and sleep medicine departments of Assiut University. Patients diagnosed with OSA through overnight polysomnography will be assessed for the presence and severity of PH using echocardiography. The study aims to determine whether OSA serves as an independent risk factor for PH and whether the severity of OSA, as measured by apnea-hypopnea index (AHI) and oxygen desaturation index (ODI), correlates with echocardiographic indicators of PH. Data will be analyzed using standardized statistical methods to establish links between OSA severity and hemodynamic changes.
Inclusion Criteria:
Adults aged 18-65 years
Diagnosed with obstructive sleep apnea (OSA) by full-night polysomnography
Apnea-Hypopnea Index (AHI) ≥ 5 events/hour
Exclusion Criteria:
Secondary pulmonary hypertension due to:Chronic pulmonary diseases, Left ventricular heart disease and Chronic thromboembolic disorders
Use of pulmonary vasodilator therapy
Long-term oxygen therapy (LTOT)
Respiratory neuromuscular weakness
Chest wall deformities
End-organ failure (cardiac, renal, hepatic)
Malignancy
Obesity hypoventilation syndrome