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| Name | Class |
|---|---|
| UHasselt | UNKNOWN |
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Fatigue is one of the most common and burdensome symptoms of MS, but its precise cause remains unknown, and an effective treatment is lacking. Previous research has shown that the progression of MS is associated with a higher presence of a specific type of T-cell, the cytotoxic CD4+ T-cells, which play a role in the immune system.
The aim of this study is to investigate whether these cells can also be linked to fatigue in people with MS.
Forty individuals with MS will be asked to complete questionnaires about fatigue and perform motor tasks. Additionally, blood samples will be taken to measure the levels of cytotoxic CD4+ T-cells. These values will then be correlated with fatigue scores and performance on the motor tasks.
Scores from the fatigue questionnaires and decline in amplitude and frequency from the performance fatiguability test will be correlated to the level of CD4 CTLs from the blood samples. Secondary study parameters include muscle activation patterns measured by EMG, distance walked on 6MWT and voluntary muscle activation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MS | Participants with multiple sclerosis |
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| Measure | Description | Time Frame |
|---|---|---|
| Correlation between percentage of cytotoxic CD4+ T cells and FSS score | Bivariate correlations will be calculated between the percentage of cytotoxic CD4+ T cells and fatigue, measured with Fatigue Severity Scale (FSS). | Day 1 |
| Correlation between percentage of cytotoxic CD4+ T cells and MFIS score | Bivariate correlations will be calculated between the percentage of cytotoxic CD4+ T cells and fatigue, measured with Modified Fatigue Impact Scale (MFIS). | Day 1 |
| Correlation between percentage of cytotoxic CD4+ T cells and foot-tapping frequency decrease | Bivariate correlations will be calculated between the percentage of cytotoxic CD4+ T cells and fatigability, measured as the decrease in frequency from the first 10 seconds of the task to the last 10 seconds of the task. | Day 1 |
| Correlation between percentage of cytotoxic CD4+ T cells and foot-tapping amplitude decrease | Bivariate correlations will be calculated between the percentage of cytotoxic CD4+ T cells and fatigability, measured as the decrease in amplitude from the first 10 seconds of the task to the last 10 seconds of the task. | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in muscle activation during 6MWT | Comparison of the root-mean-square (RMS) of the EMG signal at the beginning of the task and the end of the task. | Day 1 |
| Changes in muscle activation during foot tapping task |
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Inclusion Criteria:
Exclusion Criteria:
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40 pwMS
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UMCG | Groningen | Netherlands |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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Whole blood
Comparison of the root-mean-square (RMS) of the EMG signal at the beginning (first 10 seconds) of the task and the end (last 10 seconds) of the task.
| Day 1 |
| Correlation changes in walking distance between the first and last minute of the 6MWT and CD4+ CTLs | Changes in distance between the first minute and the last minute of the 6MWT are measured to assess walking fatigability and will be correlated with the percentage of CD4+ CTLs in the blood. | Day 1 |
| Correlation percentage voluntary muscle activation and CD4+ CTLs | The correlation is calculated between the percentage of CD4+ CTLs in the blood and the percentage of voluntary activation (1 - superimposed twitch/initial-doublet) x 100%). | Day 1 |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |