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BACKGROUND Frailty, regarded as a potentially reversible process and defined as a progressive deterioration of physiological systems and intrinsic capacity, constitutes a key risk factor for disability, dependency and institutionalisation.
Currently, it is estimated that between 50% and 75% of older adults living in residential care facilities present with frailty. This clinical profile is often directly associated with multiple comorbidities (around 65-85% of this population suffer from several chronic conditions), emotional decline, polypharmacy, malnutrition and a high prevalence of functional and cognitive impairment. Consequently, two out of every three older adults will require long-term care in specialised centres during their lifetime. In this context, nursing homes represent a key setting not only for providing care, but also for the prevention, detection and management of conditions such as frailty. However, care in residential facilities continues to focus on addressing established problems, with low participation in activities with potential benefits and a high perception of loneliness. Therefore, interventions in these contexts aimed at improving frailty are both necessary and urgent, particularly those that integrate a biopsychosocial approach, promote autonomy and foster active ageing.
Several studies have demonstrated that multidisciplinary intervention programmes and multicomponent physical training are effective in preventing frailty and its consequences. Nevertheless, their widespread implementation is limited by several factors. On the one hand, there is a lack of scientific evidence on the cost-effectiveness of such interventions, and on the other, healthcare systems face budgetary constraints in a context of increasing demand for geriatric care. In the search for more effective interventions to improve frailty and other related variables in older adults residing in nursing homes, supervised multidisciplinary programmes, delivered by health sciences students and implemented by nursing students, may represent a viable alternative. In this regard, students of Physical Activity and Sport Sciences (CAFYD) possess the knowledge required to design physical activity plans adapted to the capacities and needs of older adults. However, given the nature of their care role, nurses provide added value: their continuous presence in the clinical setting enables them to establish a closer therapeutic bond with the patient, ensure thorough monitoring of their progress, and facilitate coordination between physicians and other healthcare team members. These features make nurses key agents in the implementation of comprehensive, person-centred interventions.
Despite the potential of implementing a multidisciplinary intervention programme through health sciences students to improve frailty in older adults living in residential facilities, to the best of our knowledge, no similar interventions exist. Therefore, it is necessary to assess the feasibility of implementing such a proposal prior to conducting a randomised controlled trial to confirm its clinical effectiveness, as this approach plays an important role in determining the most appropriate trial design. To this end, different feasibility study guidelines recommend including variables such as acceptance, adherence and dropout rates as key markers for successful implementation.
STUDY'S HYPOTHESIS The main hypothesis of the CUIDAFRAIL project is that a supervised multidisciplinary intervention programme carried out by nursing and Physical Activity and Sport Sciences students is feasible for improving frailty and other related variables in older adults living in residential care facilities.
AIM AND OBJECTIVES The aim of the CUIDAFRAIL project is to examine the short- term and medium-term effects of a nursing students' multidisciplinary intervention programme on frailty among older adults living in nursing homes.
The secondary objectives of this project are the following:
STUDY DESIGN A feasibility study will be carried out. Participants will be randomly assigned to either an intervention group (IG) or a control group (CG).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | Participants allocated to the 'intervention group' arm will receive the usual care offered by the Public Andalusian Healthcare Service in conjunction with a 12-week nursing students' intervention programme. |
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| Control group | Active Comparator | Participants allocated to the 'control group' arm will only receive the usual care offered by the Public Andalusian Healthcare Service for 12 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nursing students' intervention programme | Behavioral | 12-week intervention programme conducted by nursing students and students trained in Sciences of Physical Activity and Sport (CAFYD). Participants will receive weekly three sessions of 45-60 minutes. It will include physical exercise and occupational therapy sessions aimed at improving frailty and other related outcomes in the participating older adults through interdisciplinary collaboration and ongoing monitoring. Nursing students will implement personalised intervention programmes designed by a multidisciplinary team comprising CAFYD students, an occupational therapist, and nurses experienced in the care of older adults. |
| Measure | Description | Time Frame |
|---|---|---|
| Adoption | The proportion of older adults who agree to participate out of the total number of older adults offered the programme. This information will be obtained from the records of eligible individuals and those ultimately included. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Adherence | Adherence: The proportion of participants who complete at least 8 of the 12 weeks comprising the entire programme. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Dropout | The proportion of participants who withdraw from the intervention out of the total number of individuals who agreed to participate and began the programme. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Perceived quality of the intervention | Assessed using the Net Promoter Scale (NPS), a tool used to measure user satisfaction with an intervention through the question: "How likely are you to recommend this to someone in a similar situation?" Scores range from 0 to 10, with scores below 5 indicating dissatisfaction and scores above 5 indicating satisfaction. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Measure | Description | Time Frame |
|---|---|---|
| Physical condition (SPPB total score) | This will be evaluated using the Short Physical Performance Battery (SPPB). The SPPB assesses the ability to maintain balance for 10 seconds in different positions, the time required to walk 4 metres, and the time required to rise from a chair five times. Each test is scored from 0 to 4, where 4 indicates the highest performance and 0 indicates an inability to complete the test. The total battery score ranges from 0 (worst performance) to 12 (best performance). |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad de Almería | Almería | Spain | 04120 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34812790 | Background | Teresi JA, Yu X, Stewart AL, Hays RD. Guidelines for Designing and Evaluating Feasibility Pilot Studies. Med Care. 2022 Jan 1;60(1):95-103. doi: 10.1097/MLR.0000000000001664. | |
| 38651183 | Background | Lockwood EB, Schober M. Factors Influencing the impact of nurse practitioners' clinical autonomy: a self determining perspective. Int Nurs Rev. 2024 Jun;71(2):375-395. doi: 10.1111/inr.12948. Epub 2024 Apr 23. |
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A database with the participants' total scores for the study's primary and secondary outcome measures will be made available to other researchers once all the papers presenting the study's results have been published.
The study protocol will be made available to other researchers once it has been published in a scientific journal (estimated timeframe: starting December 2026) and will be available for 6 months.
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
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Older adults who meet the inclusion criteria and voluntarily accept to participate in this study will be randomly allocated to one of two arms: intervention group (arm 1) or control group (arm 2). Participants from both arms will be assessed at the same time for data collection purposes (pre-test, post-test and 6-month follow-up) and they will be exposed to the experimental condition (intervention group) or the control condition (control group) at the same time for 12-weeks.
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The type of intervention on which the project is based does not allow for the participants to be masked and they will know to which group they are allocated. However, the team that will collect data (assessors) will not know the group to which each participant is allocated. To ensure assessor masking, participants will be instructed to never reveal the group to which they have been assigned and assessors will be instructed to never ask the participants to which group they have been assigned. The assessors will not participate in the recruitment process, the supervision of nursing students' interventions, nor the data analysis process. The group to which the participants have been allocated will be numerically coded (not labelled) in the database and the researchers in charge of data analysis will not know which numerical code refers to the intervention group and which code refers to the control group.
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| Standard care from Public Andalusian Health Service | Behavioral | They will receive the standard care provided by the Andalusian Health Service as part of its portfolio of services offered to older adults residing in institutions, as well as the standard care provided by the institutions in which they live. As part of these services, older adults receive support such as accommodation, laundry, health promotion activities, health monitoring, assistance with activities of daily living, individual, group, and community social care, as well as means of communication with the outside world. The action plans or protocols established in care processes for older adults living in nursing homes do not include externally delivered multidisciplinary intervention programmes. |
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| Frailty |
Clinical Frailty Scale (CFS). The CFS is a clinician-administered scale comprising nine levels that classify patients' degree of frailty. Each level describes a set of characteristics related to physical condition, functionality, and cognitive status, ranging from 1 (very fit) to 9 (terminally ill). Scores are assigned based on the patient's overall functioning in daily life, including mobility, dependence for basic and instrumental activities of daily living, presence of chronic diseases, and cognitive impairment. The scale has been validated in residential settings and can also be used in individuals with cognitive impairment, as it does not require self-reporting. Higher scores indicate greater frailty. |
| [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Physical condition (Timed Up and Go test) | Additionally, the Timed Up and Go (TUG) test will be used due to its association with fall risk. This test measures the time a participant takes to rise from a chair, walk 3 metres at their usual pace in a straight line, and return to a seated position. Shorter TUG times are considered indicative of better performance. A time exceeding 12 seconds is considered high fall risk; 10-12 seconds indicates moderate risk; and times below 10 seconds generally reflect good mobility and low fall risk. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Leg strength | Leg strength will be assessed using the modified thirty-second chair stand test (m-30s-CST). Participants will be asked to sit in a chair with armrests of identical dimensions for all participants. They will attempt to rise from the chair to a full standing position as many times as possible within 30 seconds. Completing 10 or more repetitions indicates good leg strength and high mobility; 8-9 repetitions correspond to moderate strength and mobility; fewer than 8 repetitions indicate low leg strength and may be associated with increased fall risk. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Grip strength | Grip strength will be evaluated given its documented correlation with frailty. It will be measured using a digital hand dynamometer (TAKEI TKK-5401) unilaterally, distinguishing between dominant and non-dominant hand. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Fall risk | The Downton Fall Risk Index will be used. This instrument comprises five sections assessing: previous falls, medication (particularly psychotropic drugs), sensory deficits, mental status, and gait. Each item has a specific score, and the total sum provides an estimate of overall fall risk. Each item can be scored 0 or 1, with a total score of 3 or more indicating a high risk of falls. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Functionality | This will be measured using the Measure of Functional Independence (MIF). The scale includes 18 items, 13 of which are related to physical activities divided into four categories: self-care, continence, transfers, and mobility. The remaining five items assess cognitive and social aspects, divided into communication and social cognition categories. Total scores range from 18 to 126, with higher scores indicating greater independence. The psychometric properties of the MIF are adequate. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Fear of falling | This will be assessed using the Short Falls Efficacy Scale-International (SFES-I), a quick and easy-to-administer scale with seven items related to different activities of daily living (ADLs) both inside and outside the home. Each item is scored from 1 (not at all concerned about falling during the activity) to 4 (very concerned about falling during the activity). Total scores range from 7 (no concern about falling) to 28 (extremely concerned). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Nutritional status | Nutritional status will be assessed using the Short Form Mini Nutritional Assessment (MNA-SF). This consists of six brief questions covering key aspects of nutritional status. Total scores (maximum 14 points) classify participants as: normal nutritional status (12-14 points), at risk of malnutrition (8-11 points), or malnourished (0-7 points). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Cognitive status | Cognitive function will be evaluated using the Mini-Mental State Examination (MMSE). This questionnaire assesses five dimensions: orientation, attention and calculation, memory, language, and praxis. Results are interpreted as follows: >24 points indicates no cognitive impairment, 19-23 points mild cognitive impairment, 14-18 points moderate cognitive impairment, and <14 points severe cognitive impairment. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Pain level | Pain will be assessed using the Pain Assessment in Advanced Dementia (PAINAD) scale. This evaluates five items: breathing, negative vocalisation, facial expression, body language, and consolability. Scores correspond to: 0-4 points mild pain, 5-7 points moderate pain, and 8-10 points severe pain. This scale can be used in patients with or without cognitive impairment. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Prediction of pressure ulcer risk | The Braden Scale will be used. This scale evaluates six dimensions: sensory perception, moisture, activity, mobility, nutrition, and friction/shear. A total score of ≤12 indicates high risk of developing pressure injuries, 13-14 indicates moderate risk, and ≥15 indicates low risk. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Quality of life among older adults | This will be assessed using the EQ-5D-5L questionnaire. The scale has two parts: a five-question survey and a visual analogue scale (VAS). The five questions measure health-related quality of life (HRQoL) in five dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) on a Likert scale (1 = no problems; 5 = extreme problems). Responses are converted into a single index value ranging from 0 (equivalent to death) to 1 (optimal health), applying Spanish population utility index values. The validated version for the general Spanish-speaking population will be used in this study. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Perceived social support | This will be assessed using the DUKE-UNC-11 Perceived Social Support Questionnaire (DUKE-11). The DUKE-11 is self-administered and measures perceived functional social support across 11 items divided into two dimensions: 'confidential support' and 'affective support'. All items use a five-point Likert scale (1 = as much as desired; 5 = much less than desired) to indicate the frequency of social support received. Scores range from 11-55 points, with scores >32 indicating low perceived social support. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Loneliness | Loneliness will be assessed using the three-item version of the UCLA Loneliness Scale (UCLA-3). The UCLA-3 measures subjective perception of loneliness through three items addressing key aspects of social disconnection. Participants respond using a three-point Likert scale (1 = never, 2 = sometimes, 3 = always). Total scores range from 3-9 points, with higher scores indicating greater perceived social isolation and lower scores indicating less loneliness. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Coping self-efficacy | This will be assessed using the Coping Self-Efficacy Scale (CSES). This scale measures an individual's perceived confidence in their ability to manage stressful or challenging situations. It comprises 26 items, each rated on an 11-point Likert scale (0 = "cannot do at all," 10 = "can do without difficulty"), grouped into three dimensions: use of coping strategies, emotional control, and positive thinking. Higher scores indicate greater perceived self-efficacy in coping with stress. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Emotional status | This will be measured using the Hospital Anxiety and Depression Scale (HADS), which assesses levels of anxiety and depression. The scale consists of 14 questions with four response options (0-3 points), seven items relating to anxiety and seven to depression. The maximum score for each subscale is 21, with a total maximum of 42 points. Scores above 11 on each subscale indicate the presence of anxiety or depression. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Glycated hemoglobin (HbA1c) | HbA1c (%) will be measured in blood samples as an indicator of long-term glucose metabolism. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Fasting blood glucose | Fasting glucose concentration (mg/dL) will be measured in blood samples as an indicator of short-term glucose metabolism. | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| High-density lipoproteins (HDL) | Serum HDL cholesterol levels (mg/dL). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Low-density lipoproteins (LDL) | Serum LDL cholesterol levels (mg/dL). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Total cholesterol | Serum total cholesterol levels (mg/dL). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Omega-3 polyunsaturated fatty acids (N-3 PUFA) | Plasma concentration of N-3 PUFA (µmol/L). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Serum albumin | Serum albumin concentration (g/dL). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| C-reactive protein (CRP) | Serum CRP concentration (mg/L). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Interleukin-6 (IL-6) | Serum IL-6 concentration (pg/mL) | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Tumour necrosis factor-alpha (TNF-α) | Serum TNF-α concentration (pg/mL). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Gamma-glutamyl transferase (GGT) | Serum GGT activity (U/L). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Aspartate aminotransferase (AST) | Serum AST activity (U/L). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
| Alanine aminotransferase (ALT) | Serum ALT activity (U/L). | [Time Frame: T1=pre-test (immediately before being enrolled onto one of the groups); T2=post-test (between 1-12 days after the visit programme has been completed); T3=6-month follow-up (six months after finishing the intervention programme)] |
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