The Impact of Hepatic Steatosis on Survival After Pancreaticoduodenectomy

The Impact of Hepatic Steatosis on Survival After Pancreaticoduodenectomy for Resectable Pancreatic Cancer. A Multifactorial Analysis of Metabolic Dysfunction

We will use simple summaries, educational handouts, and discussions with doctors and nurses to explain this study. The study looks at patients with early-stage pancreatic cancer who undergo pancreaticoduodenectomy (Whipple surgery). We found that some patients develop fatty liver (non-alcoholic fatty liver disease, NAFLD) within six months after surgery, which can affect nutrition, blood sugar control, and long-term survival.

To help patients and families understand, we will:

1. Provide clear written information sheets about the purpose of the study and its findings.
2. Use diagrams or plain-language explanations of terms like "pancreatic exocrine function" and "fatty liver."
3. Share results with healthcare providers so they can guide patients in nutrition, enzyme replacement, diabetes monitoring, and follow-up care.
4. Offer contact information for the research team to answer questions.

Inclusion Criteria:

• Adults with stage I-II pancreatic ductal adenocarcinoma.
• Underwent curative-intent pancreaticoduodenectomy (conventional or pylorus-preserving).
• Surgery between January 2015 and May 2023.
• Complete clinical and imaging data available.
• Survived at least 6 months postoperatively.

Exclusion Criteria:

• Preoperative hepatic steatosis
• Incomplete clinical or imaging data
• Death within 6 months after surgery