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The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients.
The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. The main results were: a particularly high incidence of modifiable risk factors affecting 86% of patients, with smoking being the primary cause in 75% of them.The clinical presentation found chest pain in more than 90% of cases. The pathophysiological forms of acute coronary syndrome identified the culprit artery in 90% of cases, a form without obstruction (MINOCA) was found in 17.8% of ST segment elevation infarctions (STEMI), spontaneous dissection in 14.6% of STEMI and 16.3% of NSTEMI.At 12 months, follow-up showed no cardiovascular deaths and two deaths related to neoplastic causes. At the end of this follow-up, 90% had no events. Compared to existing studies, these event rates are extremely low. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients. The secondary objective is the evaluation of the quality of life and mental health of women who have had an MI before the age of 50 years at a distance from the acute event.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| WAMIF patients | All patients who participated in the WAMIF study (NCT 03073447) and wish to continue follow-up in the present "WAMIF-suivi" study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Questionnaires | Other | Assessment of stress and anxiety and quality of life after myocardial infarct:
|
| Measure | Description | Time Frame |
|---|---|---|
| Death from any cause | Number of patient who died from any cause since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Cardiovascular death | Number of patient who died from cardiovascular cause since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Stent thrombosis | Number of patient who had stent thrombosis since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Stroke | Number of patient who had stroke since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Recurrent myocardial infarct | Number of patient who had recurrent myocardial infarct since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Emergency revascularization | Number of patient who had emergency revascularization since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Major bleeding | Number of patient who had since major bleeding their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Measure | Description | Time Frame |
|---|---|---|
| Stress score | Perceived Stress Scale 4 items. It provides a total score (range 10-50, from worst to best) to assess the state of stress perceived by the patient | 5 to 10 years after the participation in WAMIF study |
| Anxiety score |
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All patients who participated in the WAMIF study (research registration number with the French Ministry of Health : 2015-A01263-46 / Protocol registration with Clinical Trials NCT03073447) and wish to continue follow-up in the study.
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314 women who had a myocardial infarction at less than 50 years, included in the WAMIF study conducted from 2017 to 2019 in 30 French research centers.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tessa BERGOT, MSc | Contact | +33144907033 | tessa.bergot@sfcardio.fr |
| Name | Affiliation | Role |
|---|---|---|
| Stéphane MANZO SILBERMAN, MD | Hôpital de la Pitié-Salpêtrière, APHP | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital de la Pitié Salpétrière | Recruiting | Paris | 75012 | France |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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|
| Major events | Other | Collection of information related to major events occurring since inclusion in the WAMIF study |
|
| Emergency hospitalization for heart failure | Number of patient who had emergency hospitalization for heart failure since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
| Emergency department visit | Number of patient who went to emergency department since their participation in WAMIF study | 5 to 10 years after the participation in WAMIF study |
Generalized Anxiety Disorder 7 items. It provides a total score to evaluate patient anxiety (range 0 to 21: 0-4: minimal anxiety; 5-9: mild anxiety; 10-14: moderate anxiety; 15-21: severe anxiety)
| 5 to 10 years after the participation in WAMIF study |
| Depression score | Patient Health Questionnaire 9 items. It provides a total score (range 0-27, 1-4 minimal depression; 5-9 mild depression; 10-14 moderate depression; 15-19 moderately severe depression; 20-27 severe depression) to diagnose and measure severity of depression. | 5 to 10 years after the participation in WAMIF study |
| Quality of life score | European Quality of Life 5 Dimensions. It provides a total score (range 0-100, from worst to the best) to evaluate the generic quality of life | 5 to 10 years after the participation in WAMIF study |
| Quality of life score | 12 Item Short Form General Health Survey. It determines a respondent's profile in eight fields: physical function, physical role, physical pain, general health, vitality, social functioning, emotional role, and mental health | 5 to 10 years after the participation in WAMIF study |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |