Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients

Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients: the BGM-FI Study

When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by centrifugation, and the serum sample is frozen for final centralized biomarker detection), and measure the antral movement index under ultrasound (300ml of warm water is injected into the stomach before measurement, and then the antral movement is observed for 6 minutes) Then, monitor whether the patient has developed feeding intolerance within 7 days of the ICU

Inclusion Criteria:

• Age ≥18 years
• Presence of one or more organ system failures within 24 hours of ICU admission (SOFA score ≥2)
• Expected ICU stay >48 hours
• Inability to take oral nutrition
• No contraindications to enteral nutrition (EN)

Exclusion Criteria:

• Patients who have already received enteral nutrition prior to gastric antral motility measurement or biomarker collection
• Receiving palliative care with expected death within 48 hours
• Pregnancy
• Participation in another clinical trial